Positron emission tomography (PET) uses radioactive tracers and enables the functional
imaging of several metabolic processes, blood flow measurements, regional chemical …

Neuroinflammation play an important role in Alzheimer's disease pathogenesis. Advances in
molecular imaging using positron emission tomography have provided insights into the time …

Astrocytic contributions to Alzheimer's disease (AD) progression were, until recently, largely
overlooked. Astrocytes are integral to normal brain function and astrocyte reactivity is an …

Astrocytes are highly efficient homeostatic glial cells playing a crucial role in optimal brain
functioning and homeostasis. Astrocytes respond to changes in brain homoeostasis …

The dynamic and multicellular processes of neuroinflammation are mediated by the
nonneuronal cells of the central nervous system, which include astrocytes and the brain's …

Abstract 11C-BU99008 is a novel positron emission tomography (PET) tracer that enables
selective imaging of astrocyte reactivity in vivo. To explore astrocyte reactivity associated …

Purpose A limit on developing new treatments for a number of central nervous system (CNS)
disorders has been the inadequate understanding of the in vivo pathophysiology underlying …

Imidazoline receptors historically referred to a family of nonadrenergic binding sites that
recognize compounds with an imidazoline moiety, although this has proven to be an …

Many neurodegenerative diseases are neuropathologically characterized by neuronal loss,
gliosis, and the deposition of misfolded proteins such as β-amyloid (Aβ) plaques and tau …

With reactive astrogliosis being established as one of the hallmarks of Alzheimer's disease
(AD), there is high interest in developing novel positron emission tomography (PET) tracers …