Safety and efficacy constitute the major criteria governing regulatory approval of any new
drug. The best method to maximize safety and efficacy is to deliver a proven therapeutic …

The folate receptor (FR) is a recognised biomarker for tumour cells due to its overexpression
on a large number of tumours. Consequently, the FR has been exploited by many diagnostic …

Most cancer drugs are designed to interfere with one or more events in cell proliferation or
survival. As healthy cells may also need to proliferate and avoid apoptosis, anticancer …

During the last decades, a plethora of nanoparticles have been developed and evaluated
and a real hype has been created around their potential application as diagnostic and …

Background Mirvetuximab soravtansine (MIRV) is an antibody-drug conjugate comprising a
folate receptor alpha (FRα)-binding antibody, cleavable linker, and the maytansinoid DM4, a …

Promising targeted treatments and immunotherapy strategies in oncology and
advancements in our understanding of molecular pathways that underpin cancer …

Background In cancer therapy, molecularly targeted agents have the potential to maximize
antitumor efficacy while minimizing treatment-related toxicity. However, these agents may …

Theranostics has emerged in recent years to provide an efficient and safer alternative in
cancer management. This review presents an updated description of nanotheranostic …

Objective Through binding to folate receptor-β (FR-β), the new 99m Tc–EC20 (Etarfolatide)
imaging technique detects activated but not resting macrophages in vivo. The goal of this …

Ovarian cancer is a high-mortality malignancy in women. The contemporary clinical
chemotherapy with classic cytotoxic drugs, targeted molecular inhibitors would mostly fail …