Immuno-positron emission tomography (immunoPET) is a paradigm-shifting molecular
imaging modality combining the superior targeting specificity of monoclonal antibody (mAb) …

Highlights•Non-antibody scaffold drugs are a promising new class of biologics drugs.•The
first candidate scaffolds are now moving into clinical development and practice.•Challenges …

Non-immunoglobulin (non-Ig) scaffolds are, in contrast to antibodies, small single-domain
proteins that require no post-translational modification, often lack disulfide bonds, and can …

Immuno-positron emission tomography (immunoPET) is a molecular imaging modality
combining the high sensitivity of PET with the specific targeting ability of monoclonal …

The emergence of novel binding proteins or antibody mimetics capable of binding to ligand
analytes in a manner analogous to that of the antigen–antibody interaction has spurred …

Introduction Anticalin proteins are engineered versions of lipocalins that constitute a novel
class of clinical-stage biopharmaceuticals. The lipocalins exhibit a central β-barrel with eight …

Although antibodies are well developed and widely used in cancer therapy and diagnostic
fields, some defects remain, such as poor tissue penetration, long in vivo metabolic …

Small engineered scaffold proteins have attracted attention as probes for radionuclide-
based molecular imaging. One class of these imaging probes, termed ABD-Derived Affinity …

Antibodies have been indispensable tools in molecular biology, biochemistry and medical
research. However, a number of issues surrounding validation, specificity and batch …

Engineered scaffold proteins (ESP) are high-affinity binders that can be used as probes for
radionuclide imaging. Histidine-containing tags enable both efficient purification of ESP and …