Glutamate and dopamine in schizophrenia: An update for the 21st century
O Howes, R McCutcheon… - Journal of …, 2015 - journals.sagepub.com
The glutamate and dopamine hypotheses are leading theories of the pathoaetiology of
schizophrenia. Both were initially based on indirect evidence from pharmacological studies …
schizophrenia. Both were initially based on indirect evidence from pharmacological studies …
[HTML][HTML] Mapping neurotransmitter systems to the structural and functional organization of the human neocortex
Neurotransmitter receptors support the propagation of signals in the human brain. How
receptor systems are situated within macro-scale neuroanatomy and how they shape …
receptor systems are situated within macro-scale neuroanatomy and how they shape …
[HTML][HTML] A review of molecular imaging of glutamate receptors
JH Kim, J Marton, SM Ametamey, P Cumming - Molecules, 2020 - mdpi.com
Molecular imaging with positron emission tomography (PET) and single photon emission
computed tomography (SPECT) is a well-established and important in vivo technique to …
computed tomography (SPECT) is a well-established and important in vivo technique to …
[PDF][PDF] Imaging transcriptomics: Convergent cellular, transcriptomic, and molecular neuroimaging signatures in the healthy adult human brain
The integration of transcriptomic and neuroimaging data," imaging transcriptomics," has
recently emerged to generate hypotheses about potential biological pathways underlying …
recently emerged to generate hypotheses about potential biological pathways underlying …
[HTML][HTML] Molecular imaging of schizophrenia: Neurochemical findings in a heterogeneous and evolving disorder
The past four decades have seen enormous efforts placed on a search for molecular
markers of schizophrenia using positron emission tomography (PET) and single photon …
markers of schizophrenia using positron emission tomography (PET) and single photon …
[HTML][HTML] Validation of a combined image derived input function and venous sampling approach for the quantification of [18F] GE-179 PET binding in the brain
Blood-based kinetic analysis of PET data relies on an accurate estimate of the arterial
plasma input function (PIF). An alternative to invasive measurements from arterial sampling …
plasma input function (PIF). An alternative to invasive measurements from arterial sampling …
[HTML][HTML] Synaptic and neuronal autoantibody-associated psychiatric syndromes: controversies and hypotheses
A Al-Diwani, TA Pollak, AE Langford… - Frontiers in …, 2017 - frontiersin.org
Autoimmune encephalitis (AE) mediated by antibodies against synaptic and neuronal
surface targets frequently presents with a psychiatric syndrome. In these patients, removal of …
surface targets frequently presents with a psychiatric syndrome. In these patients, removal of …
[HTML][HTML] N-methyl-D-aspartate receptor availability in first-episode psychosis: a PET-MR brain imaging study
K Beck, A Arumuham, M Veronese… - Translational …, 2021 - nature.com
N-methyl-D-aspartate receptor (NMDAR) hypofunction is hypothesised to underlie psychosis
but this has not been tested early in illness. To address this, we studied 40 volunteers (21 …
but this has not been tested early in illness. To address this, we studied 40 volunteers (21 …
Positron Emission Tomography (PET) Ligand Development for Ionotropic Glutamate Receptors: Challenges and Opportunities for Radiotracer Targeting N-Methyl-d …
H Fu, Z Chen, L Josephson, Z Li… - Journal of medicinal …, 2018 - ACS Publications
Ionotropic glutamate receptors (iGluRs) mediate excitatory neurotransmission within the
mammalian central nervous system. iGluRs exist as three main groups: N-methyl-d …
mammalian central nervous system. iGluRs exist as three main groups: N-methyl-d …
HIF‐1α triggers long‐lasting glutamate excitotoxicity via system xc− in cerebral ischaemia–reperfusion
Hypoxia‐inducible factor 1α (HIF‐1α) controls many genes involved in physiological and
pathological processes. However, its roles in glutamatergic transmission and excitotoxicity …
pathological processes. However, its roles in glutamatergic transmission and excitotoxicity …