11 C [double bond, length as m-dash] O bonds made easily for positron emission tomography radiopharmaceuticals
The positron-emitting radionuclide carbon-11 (11C, t1/2= 20.3 min) possesses the unique
potential for radiolabeling of any biological, naturally occurring, or synthetic organic …
potential for radiolabeling of any biological, naturally occurring, or synthetic organic …
Molecular imaging of hydrolytic enzymes using PET and SPECT
Hydrolytic enzymes are a large class of biological catalysts that play a vital role in a plethora
of critical biochemical processes required to maintain human health. However, the …
of critical biochemical processes required to maintain human health. However, the …
[HTML][HTML] Elevated fatty acid amide hydrolase in the prefrontal cortex of borderline personality disorder: a [11C]CURB positron emission tomography study
Amygdala-prefrontal cortex (PFC) functional impairments have been linked to emotion
dysregulation and aggression in borderline personality disorder (BPD). Fatty acid amide …
dysregulation and aggression in borderline personality disorder (BPD). Fatty acid amide …
Fatty acid amide hydrolase binding in brain of cannabis users: imaging with the novel radiotracer [11C] CURB
Background One of the major mechanisms for terminating the actions of the
endocannabinoid anandamide is hydrolysis by fatty acid amide hydrolase (FAAH), and …
endocannabinoid anandamide is hydrolysis by fatty acid amide hydrolase (FAAH), and …
[HTML][HTML] Lower amygdala fatty acid amide hydrolase in violent offenders with antisocial personality disorder: an [11C]CURB positron emission tomography study
Antisocial personality disorder (ASPD) imposes a high societal burden given the repetitive
reactive aggression that affected individuals perpetrate. Since the brain endocannabinoid …
reactive aggression that affected individuals perpetrate. Since the brain endocannabinoid …
[HTML][HTML] Higher trait neuroticism is associated with greater fatty acid amide hydrolase binding in borderline and antisocial personality disorders
Borderline personality disorder (BPD) and antisocial personality disorder (ASPD) are the
two most frequently diagnosed and researched DSM-5 personality disorders, and both are …
two most frequently diagnosed and researched DSM-5 personality disorders, and both are …
Blocking of Fatty Acid Amide Hydrolase Activity with PF-04457845 in Human Brain: A Positron Emission Tomography Study with the Novel Radioligand [11C]CURB
I Boileau, PM Rusjan, B Williams… - Journal of Cerebral …, 2015 - journals.sagepub.com
Positron emission tomography with [11C] CURB was recently developed to quantify fatty
acid amide hydrolase (FAAH), the enzyme responsible for hydrolyzing the endocannabinoid …
acid amide hydrolase (FAAH), the enzyme responsible for hydrolyzing the endocannabinoid …
Fatty acid amide hydrolase: An integrative clinical perspective
AD Santoso, D De Ridder - Cannabis and Cannabinoid Research, 2023 - liebertpub.com
Introduction: Fatty acid amide hydrolase (FAAH) is one of the main terminating enzymes of
the endocannabinoid system (ECS). Since being discovered in 1996, the modulation of …
the endocannabinoid system (ECS). Since being discovered in 1996, the modulation of …
Radiochemistry with carbon‐11
S Thompson, S Kealey, SM Sephton… - Handbook of …, 2020 - Wiley Online Library
Carbon‐11 decays into stable boron‐11 and has a physical half‐life of 20.4 minutes. The
emergence of medical cyclotrons in the 1960s and positron emission tomography in the late …
emergence of medical cyclotrons in the 1960s and positron emission tomography in the late …
Synthesis and Preliminary PET Imaging Studies of a FAAH Radiotracer ([11C]MPPO) Based on α-Ketoheterocyclic Scaffold
L Wang, J Yui, Q Wang, Y Zhang, W Mori… - ACS chemical …, 2016 - ACS Publications
Fatty acid amide hydrolase (FAAH) is one of the principle enzymes for metabolizing
endogenous cannabinoid neurotransmitters such as anandamide, and thus regulates …
endogenous cannabinoid neurotransmitters such as anandamide, and thus regulates …