Positron emission tomography (PET) uses radioactive tracers and enables the functional
imaging of several metabolic processes, blood flow measurements, regional chemical …

Purpose A limit on developing new treatments for a number of central nervous system (CNS)
disorders has been the inadequate understanding of the in vivo pathophysiology underlying …

Purinergic receptors play important roles in central nervous system (CNS). These receptors
are involved in cellular neuroinflammatory responses that regulate functions of neurons …

Growing evidence emphasizes that the purine nucleoside adenosine plays an active role as
a local regulator in different pathologies. Adenosine is a ubiquitous nucleoside involved in …

Neuroinflammation is thought to play a pivotal role in many diseases affecting the brain,
including Alzheimer's disease, multiple sclerosis and stroke. Neuroinflammation is …

Adenosine and dopamine interact antagonistically in living mammals. These interactions are
mediated via adenosine A2A and dopamine D2 receptors (R). Stimulation of A2AR inhibits …

Introduction: Parkinson's disease (PD) is one of the most challenging neurodegenerative
disorders to treat as it manifests with a large variety of troublesome, and often disabling …

PET with selective adenosine 2A receptor (A2A) radiotracers can be used to study a variety
of neurodegenerative and neuropsychiatric disorders in vivo and to support drug-discovery …

Abstract Adenosine A2A receptors (A2ARs) are highly expressed in the human striatum, and
at lower densities in the cerebral cortex, the hippocampus, and cells of the immune system …

Abstract Purpose The adenosine A 2A receptor has emerged as a therapeutic target for
multiple diseases, and thus the non-invasive imaging of the expression or occupancy of the …