Copper radiopharmaceuticals for theranostic applications
A Ahmedova, B Todorov, N Burdzhiev… - European Journal of …, 2018 - Elsevier
The growing advancement in nuclear medicine challenges researchers from several
different fields to integrate imaging and therapeutic modalities in a theranostic …
different fields to integrate imaging and therapeutic modalities in a theranostic …
[HTML][HTML] Radiolabeled cetuximab conjugates for EGFR targeted cancer diagnostics and therapy
W Sihver, J Pietzsch, M Krause, M Baumann… - Pharmaceuticals, 2014 - mdpi.com
The epidermal growth factor receptor (EGFR) has evolved over years into a main molecular
target for the treatment of different cancer entities. In this regard, the anti-EGFR antibody …
target for the treatment of different cancer entities. In this regard, the anti-EGFR antibody …
64Cu-Labeled Inhibitors of Prostate-Specific Membrane Antigen for PET Imaging of Prostate Cancer
SR Banerjee, M Pullambhatla, CA Foss… - Journal of medicinal …, 2014 - ACS Publications
Prostate-specific membrane antigen (PSMA) is a well-recognized target for identification and
therapy of a variety of cancers. Here we report five 64Cu-labeled inhibitors of PSMA,[64Cu] …
therapy of a variety of cancers. Here we report five 64Cu-labeled inhibitors of PSMA,[64Cu] …
Anti-L1CAM radioimmunotherapy is more effective with the radiolanthanide terbium-161 compared to lutetium-177 in an ovarian cancer model
J Grünberg, D Lindenblatt, H Dorrer, S Cohrs… - European journal of …, 2014 - Springer
Purpose The L1 cell adhesion molecule (L1CAM) is considered a valuable target for
therapeutic intervention in different types of cancer. Recent studies have shown that anti …
therapeutic intervention in different types of cancer. Recent studies have shown that anti …
Synergism of 64Cu-Labeled RGD with Anti-PD-L1 Immunotherapy for the Long-Acting Antitumor Effect
X Wen, X Zeng, J Liu, Y Zhang, C Shi, X Wu… - Bioconjugate …, 2022 - ACS Publications
We put forward a novel targeting-triggering-therapy (TTT) scheme that combines 64Cu-
based targeted radionuclide therapy (TRT) with programmed death-ligand 1 (PD-L1)-based …
based targeted radionuclide therapy (TRT) with programmed death-ligand 1 (PD-L1)-based …
64Cu-intraperitoneal radioimmunotherapy: A novel approach for adjuvant treatment in a clinically relevant preclinical model of pancreatic cancer
Y Yoshii, H Matsumoto, M Yoshimoto… - Journal of Nuclear …, 2019 - Soc Nuclear Med
Pancreatic cancer (PC) has a very poor prognosis. Surgery is the primary treatment for
patients with resectable PC; however, local recurrence, hepatic metastasis, and peritoneal …
patients with resectable PC; however, local recurrence, hepatic metastasis, and peritoneal …
[HTML][HTML] Tetraspanin 8 (TSPAN 8) as a potential target for radio-immunotherapy of colorectal cancer
A Maisonial-Besset, T Witkowski, I Navarro-Teulon… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Abstract Tetraspanin 8 (TSPAN8) overexpression is correlated with poor prognosis in
human colorectal cancer (CRC). A murine mAb Ts29. 2 specific for human TSPAN8 …
human colorectal cancer (CRC). A murine mAb Ts29. 2 specific for human TSPAN8 …
Harnessing the Coordination Chemistry of 1, 4, 7‐Triazacyclononane for Biomimicry and Radiopharmaceutical Applications
Triazacyclononane (TACN)‐based mono‐and poly‐nuclear metal complexes have found
extensive use as biological mimics for understanding the structural and operational aspects …
extensive use as biological mimics for understanding the structural and operational aspects …
Comparison of conjugation strategies of cross-bridged macrocyclic chelators with cetuximab for copper-64 radiolabeling and PET imaging of EGFR in colorectal tumor …
Epidermal growth-factor receptor (EGFR) is overexpressed in a wide variety of solid tumors
and has served as a well-characterized target for cancer imaging and therapy. Cetuximab …
and has served as a well-characterized target for cancer imaging and therapy. Cetuximab …
Evaluation of cetuximab as a candidate for targeted α-particle radiation therapy of HER1-positive disseminated intraperitoneal disease
DE Milenic, KE Baidoo, YS Kim, MW Brechbiel - MAbs, 2015 - Taylor & Francis
Although the epidermal growth factor receptor (EGFR), also known as HER1, has been
studied for over a decade, it continues to be a molecule of great interest and focus of …
studied for over a decade, it continues to be a molecule of great interest and focus of …