[HTML][HTML] Clinical advancements in the targeted therapies against liver fibrosis

R Bansal, B Nagórniewicz, J Prakash - Mediators of inflammation, 2016 - hindawi.com
Hepatic fibrosis, characterized by excessive accumulation of extracellular matrix (ECM)
proteins leading to liver dysfunction, is a growing cause of mortality worldwide …

Human copper-dependent amine oxidases

J Finney, HJ Moon, T Ronnebaum, M Lantz… - Archives of biochemistry …, 2014 - Elsevier
Copper amine oxidases (CAOs) are a class of enzymes that contain Cu 2+ and a tyrosine-
derived quinone cofactor, catalyze the conversion of a primary amine functional group to an …

[HTML][HTML] Imaging inflammation with positron emission tomography

J Iking, M Staniszewska, L Kessler, JM Klose… - Biomedicines, 2021 - mdpi.com
The impact of inflammation on the outcome of many medical conditions such as
cardiovascular diseases, neurological disorders, infections, cancer, and autoimmune …

[HTML][HTML] Systematic review: targeted molecular imaging of angiogenesis and its mediators in rheumatoid arthritis

F Khodadust, A Ezdoglian, MM Steinz… - International journal of …, 2022 - mdpi.com
Extensive angiogenesis is a characteristic feature in the synovial tissue of rheumatoid
arthritis (RA) from a very early stage of the disease onward and constitutes a crucial event …

Molecular imaging to enlighten cancer immunotherapies and underlying involved processes

EL van der Veen, F Bensch, AWJM Glaudemans… - Cancer Treatment …, 2018 - Elsevier
Cancer immunotherapy has led to impressive antitumor effects. However, not all patients
respond to immunotherapy, serious toxicity can occur and combination therapy may be …

New radiotracers for imaging of vascular targets in angiogenesis-related diseases

H Hong, F Chen, Y Zhang, W Cai - Advanced drug delivery reviews, 2014 - Elsevier
Tremendous advances over the last several decades in positron emission tomography
(PET) and single photon emission computed tomography (SPECT) allow for targeted …

[HTML][HTML] Leukocyte trafficking-associated vascular adhesion protein 1 is expressed and functionally active in atherosclerotic plaques

JMU Silvola, H Virtanen, R Siitonen, S Hellberg… - Scientific reports, 2016 - nature.com
Given the important role of inflammation and the potential association of the leukocyte
trafficking-associated adhesion molecule vascular adhesion protein 1 (VAP-1) with …

[HTML][HTML] 68Ga-DOTA-Siglec-9 – a new imaging tool to detect synovitis

H Virtanen, A Autio, R Siitonen, H Liljenbäck… - Arthritis Research & …, 2015 - Springer
Introduction Vascular adhesion protein-1 (VAP-1) is an adhesion molecule, which upon
inflammation is rapidly translocated from intracellular sources to the endothelial cell surface …

Antibody‐Based Tracers for PET/SPECT Imaging of Chronic Inflammatory Diseases

HJ Lee, EB Ehlerding, W Cai - ChemBioChem, 2019 - Wiley Online Library
Chronic inflammatory diseases are often progressive, resulting not only in physical damage
to patients but also social and economic burdens, making early diagnosis of them critical …

Ectoenzymes in leukocyte migration and their therapeutic potential

M Salmi, S Jalkanen - Seminars in Immunopathology, 2014 - Springer
Inflammation causes or accompanies a huge variety of diseases. Migration of leukocytes
from the blood into the tissues, in the tissues, and from the tissues to lymphatic vasculature is …