[HTML][HTML] Advances in CNS PET: the state-of-the-art for new imaging targets for pathophysiology and drug development
SP McCluskey, C Plisson, EA Rabiner… - European journal of …, 2020 - Springer
Purpose A limit on developing new treatments for a number of central nervous system (CNS)
disorders has been the inadequate understanding of the in vivo pathophysiology underlying …
disorders has been the inadequate understanding of the in vivo pathophysiology underlying …
Quantitative positron emission tomography in brain research
The application of positron emission tomography (PET) in brain research has increased
substantially during the past 20 years, and is still growing. PET provides a unique insight …
substantially during the past 20 years, and is still growing. PET provides a unique insight …
Quantifying SV2A density and drug occupancy in the human brain using [11C]UCB-J PET imaging and subcortical white matter as reference tissue
M Koole, J van Aalst, M Devrome, N Mertens… - European journal of …, 2019 - Springer
Abstract Purpose A [11 C] UCB-J blocking study was performed in healthy volunteers to
validate simplified, non-invasive measures for quantifying presynaptic SV2A expression …
validate simplified, non-invasive measures for quantifying presynaptic SV2A expression …
PET imaging shows loss of striatal PDE10A in patients with Huntington disease
R Ahmad, S Bourgeois, A Postnov, ME Schmidt… - Neurology, 2014 - AAN Enterprises
Phosphodiesterase 10A (PDE10A) belongs to a family of enzymes that hydrolyze cyclic
adenosine monophosphate (cAMP) and cyclic guanosine monophosphate. 1 PDE10A is …
adenosine monophosphate (cAMP) and cyclic guanosine monophosphate. 1 PDE10A is …
Advances in cyclic nucleotide phosphodiesterase-targeted PET imaging and drug discovery
Cyclic nucleotide phosphodiesterases (PDEs) control the intracellular concentrations of
cAMP and cGMP in virtually all mammalian cells. Accordingly, the PDE family regulates a …
cAMP and cGMP in virtually all mammalian cells. Accordingly, the PDE family regulates a …
In vivo assessment and dosimetry of 2 novel PDE10A PET radiotracers in humans: 18F-MNI-659 and 18F-MNI-654
O Barret, D Thomae, A Tavares, D Alagille… - Journal of Nuclear …, 2014 - Soc Nuclear Med
Phosphodiesterase (PDE) 10A is an enzyme involved in the regulation of cyclic adenosine
monophosphate and cyclic guanosine monophosphate and is highly expressed in medium …
monophosphate and cyclic guanosine monophosphate and is highly expressed in medium …
Validation of Parametric Methods for [11C]UCB-J PET Imaging Using Subcortical White Matter as Reference Tissue
N Mertens, RP Maguire, K Serdons, B Lacroix… - Molecular Imaging and …, 2020 - Springer
Purpose The aim of this study was to evaluate different non-invasive methods for generating
(R)-1-((3-([11 C] methyl) pyridin-4-yl) methyl)-4-(3, 4, 5-trifluorophenyl) pyrrolidin-2-one)([11 …
(R)-1-((3-([11 C] methyl) pyridin-4-yl) methyl)-4-(3, 4, 5-trifluorophenyl) pyrrolidin-2-one)([11 …
Phosphodiesterase 10A PET radioligand development program: from pig to human
C Plisson, D Weinzimmer, S Jakobsen… - Journal of Nuclear …, 2014 - Soc Nuclear Med
Four novel phosphodiesterase 10A (PDE10A) PET tracers have been synthesized,
characterized in preclinical studies, and compared with the previously reported 11C-MP-10 …
characterized in preclinical studies, and compared with the previously reported 11C-MP-10 …
Evaluation of advanced, pathophysiologic new targets for imaging of CNS
The inadequate information about the in vivo pathological, physiological, and neurological
impairments, as well as the absence of in vivo tools for assessing brain penetrance and the …
impairments, as well as the absence of in vivo tools for assessing brain penetrance and the …
Transition-metal-free synthesis of pyridine derivatives by thermal cyclization of N-propargyl enamines
Y Chikayuki, T Miyashige, S Yonekawa, A Kirita… - …, 2020 - thieme-connect.com
A transition-metal-free synthesis of pyridine derivatives by 6-endo-dig cyclization of N-
propargyl enamines was developed. This method is environmentally friendly and is a high …
propargyl enamines was developed. This method is environmentally friendly and is a high …