Olfactory bulb involvement in neurodegenerative diseases
Olfactory dysfunction is a common and early symptom of many neurodegenerative diseases,
particularly of Parkinson's disease and other synucleinopathies, Alzheimer's disease (AD) …
particularly of Parkinson's disease and other synucleinopathies, Alzheimer's disease (AD) …
[PDF][PDF] Metabolic and non-cognitive manifestations of Alzheimer's disease: the hypothalamus as both culprit and target of pathology
M Ishii, C Iadecola - Cell metabolism, 2015 - cell.com
Alzheimer's disease (AD) is increasingly recognized as a complex neurodegenerative
disease beginning decades prior to the cognitive decline. While cognitive deficits remain the …
disease beginning decades prior to the cognitive decline. While cognitive deficits remain the …
[HTML][HTML] Pathogenic microbes, the microbiome, and Alzheimer's disease (AD)
JM Hill, C Clement, AI Pogue… - Frontiers in aging …, 2014 - frontiersin.org
Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the leading
cause of cognitive and behavioral impairment in industrialized societies. The cause of AD is …
cause of cognitive and behavioral impairment in industrialized societies. The cause of AD is …
Olfactory dysfunction in the pathophysiological continuum of dementia
P Bathini, E Brai, LA Auber - Ageing research reviews, 2019 - Elsevier
Sensory capacities like smell, taste, hearing, vision decline with aging, but increasing
evidence show that sensory dysfunctions are one of the early signs diagnosing the …
evidence show that sensory dysfunctions are one of the early signs diagnosing the …
Anosmia, mild cognitive impairment, and biomarkers of brain aging in older adults
Y Dong, Y Li, K Liu, X Han, R Liu, Y Ren… - Alzheimer's & …, 2023 - Wiley Online Library
Olfactory impairment is a potential marker for prodromal dementia, but the underlying
mechanisms are poorly understood. This population‐based study included 4214 dementia …
mechanisms are poorly understood. This population‐based study included 4214 dementia …
[HTML][HTML] Role of sex and high-fat diet in metabolic and hypothalamic disturbances in the 3xTg-AD mouse model of Alzheimer's disease
LS Robison, OJ Gannon, MA Thomas… - Journal of …, 2020 - Springer
Background Hypothalamic dysfunction occurs early in the clinical course of Alzheimer's
disease (AD), likely contributing to disturbances in feeding behavior and metabolic function …
disease (AD), likely contributing to disturbances in feeding behavior and metabolic function …
Measuring cortical connectivity in Alzheimer's disease as a brain neural network pathology: toward clinical applications
Objectives: The objective was to review the literature on diffusion tensor imaging as well as
resting-state functional magnetic resonance imaging and electroencephalography (EEG) to …
resting-state functional magnetic resonance imaging and electroencephalography (EEG) to …
[HTML][HTML] MRI-based classification models in prediction of mild cognitive impairment and dementia in late-life depression
AK Lebedeva, E Westman, T Borza… - Frontiers in aging …, 2017 - frontiersin.org
Objective: Late-life depression (LLD) is associated with development of different types of
dementia. Identification of LLD patients, who will develop cognitive decline, ie, the early …
dementia. Identification of LLD patients, who will develop cognitive decline, ie, the early …
[HTML][HTML] Insulin resistance is associated with reductions in specific cognitive domains and increases in CSF tau in cognitively normal adults
SM Laws, S Gaskin, A Woodfield, V Srikanth, D Bruce… - Scientific reports, 2017 - nature.com
Growing evidence supports the hypothesis that type 2 diabetes (T2D) increases the risk of
developing dementia. Experimental evidence from mouse models demonstrates that the …
developing dementia. Experimental evidence from mouse models demonstrates that the …
Cognitive correlates of basal forebrain atrophy and associated cortical hypometabolism in mild cognitive impairment
Degeneration of basal forebrain (BF) cholinergic nuclei is associated with cognitive decline,
and this effect is believed to be mediated by neuronal dysfunction in the denervated cortical …
and this effect is believed to be mediated by neuronal dysfunction in the denervated cortical …