Olfactory bulb involvement in neurodegenerative diseases

J Attems, L Walker, KA Jellinger - Acta neuropathologica, 2014 - Springer
Olfactory dysfunction is a common and early symptom of many neurodegenerative diseases,
particularly of Parkinson's disease and other synucleinopathies, Alzheimer's disease (AD) …

[PDF][PDF] Metabolic and non-cognitive manifestations of Alzheimer's disease: the hypothalamus as both culprit and target of pathology

M Ishii, C Iadecola - Cell metabolism, 2015 - cell.com
Alzheimer's disease (AD) is increasingly recognized as a complex neurodegenerative
disease beginning decades prior to the cognitive decline. While cognitive deficits remain the …

[HTML][HTML] Pathogenic microbes, the microbiome, and Alzheimer's disease (AD)

JM Hill, C Clement, AI Pogue… - Frontiers in aging …, 2014 - frontiersin.org
Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the leading
cause of cognitive and behavioral impairment in industrialized societies. The cause of AD is …

Olfactory dysfunction in the pathophysiological continuum of dementia

P Bathini, E Brai, LA Auber - Ageing research reviews, 2019 - Elsevier
Sensory capacities like smell, taste, hearing, vision decline with aging, but increasing
evidence show that sensory dysfunctions are one of the early signs diagnosing the …

Anosmia, mild cognitive impairment, and biomarkers of brain aging in older adults

Y Dong, Y Li, K Liu, X Han, R Liu, Y Ren… - Alzheimer's & …, 2023 - Wiley Online Library
Olfactory impairment is a potential marker for prodromal dementia, but the underlying
mechanisms are poorly understood. This population‐based study included 4214 dementia …

[HTML][HTML] Role of sex and high-fat diet in metabolic and hypothalamic disturbances in the 3xTg-AD mouse model of Alzheimer's disease

LS Robison, OJ Gannon, MA Thomas… - Journal of …, 2020 - Springer
Background Hypothalamic dysfunction occurs early in the clinical course of Alzheimer's
disease (AD), likely contributing to disturbances in feeding behavior and metabolic function …

Measuring cortical connectivity in Alzheimer's disease as a brain neural network pathology: toward clinical applications

S Teipel, MJ Grothe, J Zhou, J Sepulcre… - Journal of the …, 2016 - cambridge.org
Objectives: The objective was to review the literature on diffusion tensor imaging as well as
resting-state functional magnetic resonance imaging and electroencephalography (EEG) to …

[HTML][HTML] MRI-based classification models in prediction of mild cognitive impairment and dementia in late-life depression

AK Lebedeva, E Westman, T Borza… - Frontiers in aging …, 2017 - frontiersin.org
Objective: Late-life depression (LLD) is associated with development of different types of
dementia. Identification of LLD patients, who will develop cognitive decline, ie, the early …

[HTML][HTML] Insulin resistance is associated with reductions in specific cognitive domains and increases in CSF tau in cognitively normal adults

SM Laws, S Gaskin, A Woodfield, V Srikanth, D Bruce… - Scientific reports, 2017 - nature.com
Growing evidence supports the hypothesis that type 2 diabetes (T2D) increases the risk of
developing dementia. Experimental evidence from mouse models demonstrates that the …

Cognitive correlates of basal forebrain atrophy and associated cortical hypometabolism in mild cognitive impairment

MJ Grothe, H Heinsen, E Amaro Jr, LT Grinberg… - Cerebral …, 2016 - academic.oup.com
Degeneration of basal forebrain (BF) cholinergic nuclei is associated with cognitive decline,
and this effect is believed to be mediated by neuronal dysfunction in the denervated cortical …