[HTML][HTML] Alzheimer disease pathogenesis: insights from molecular and cellular biology studies of oligomeric Aβ and tau species
XQ Chen, WC Mobley - Frontiers in Neuroscience, 2019 - frontiersin.org
Alzheimer disease (AD) represents an oncoming epidemic that without an effective
treatment promises to exact extraordinary human and financial burdens. Studies of …
treatment promises to exact extraordinary human and financial burdens. Studies of …
[HTML][HTML] Recent advances in molecular pathways and therapeutic implications targeting neuroinflammation for Alzheimer's disease
R Dhapola, SS Hota, P Sarma, A Bhattacharyya… - …, 2021 - Springer
Alzheimer's disease (AD) is a major contributor of dementia leading to the degeneration of
neurons in the brain with major symptoms like loss of memory and learning. Many evidences …
neurons in the brain with major symptoms like loss of memory and learning. Many evidences …
Microglial activation states drive glucose uptake and FDG-PET alterations in neurodegenerative diseases
X Xiang, K Wind, T Wiedemann, T Blume… - Science translational …, 2021 - science.org
2-Deoxy-2-[18F] fluoro-d-glucose positron emission tomography (FDG-PET) is widely used
to study cerebral glucose metabolism. Here, we investigated whether the FDG-PET signal is …
to study cerebral glucose metabolism. Here, we investigated whether the FDG-PET signal is …
[PDF][PDF] Distinct molecular profiles of skull bone marrow in health and neurological disorders
The bone marrow in the skull is important for shaping immune responses in the brain and
meninges, but its molecular makeup among bones and relevance in human diseases …
meninges, but its molecular makeup among bones and relevance in human diseases …
Higher CSF sTREM2 and microglia activation are associated with slower rates of beta‐amyloid accumulation
M Ewers, G Biechele, M Suárez‐Calvet… - EMBO molecular …, 2020 - embopress.org
Microglia activation is the brain's major immune response to amyloid plaques in Alzheimer's
disease (AD). Both cerebrospinal fluid (CSF) levels of soluble TREM2 (sTREM2), a …
disease (AD). Both cerebrospinal fluid (CSF) levels of soluble TREM2 (sTREM2), a …
Opposite microglial activation stages upon loss of PGRN or TREM 2 result in reduced cerebral glucose metabolism
Microglia adopt numerous fates with homeostatic microglia (HM) and a microglial
neurodegenerative phenotype (MG nD) representing two opposite ends. A number of …
neurodegenerative phenotype (MG nD) representing two opposite ends. A number of …
[HTML][HTML] TSPO imaging in animal models of brain diseases
N Van Camp, S Lavisse, P Roost, F Gubinelli… - European Journal of …, 2021 - Springer
Over the last 30 years, the 18-kDa TSPO protein has been considered as the PET imaging
biomarker of reference to measure increased neuroinflammation. Generally assumed to …
biomarker of reference to measure increased neuroinflammation. Generally assumed to …
[HTML][HTML] Prodromal neuroinflammatory, cholinergic and metabolite dysfunction detected by PET and MRS in the TgF344-AD transgenic rat model of AD: a collaborative …
AM Chaney, FR Lopez-Picon, S Serrière, R Wang… - Theranostics, 2021 - ncbi.nlm.nih.gov
Mouse models of Alzheimer's disease (AD) are valuable but do not fully recapitulate human
AD pathology, such as spontaneous Tau fibril accumulation and neuronal loss …
AD pathology, such as spontaneous Tau fibril accumulation and neuronal loss …
[HTML][HTML] Beta-amyloid imaging with florbetaben
Abstract Florbetaben is a fluorine-18 (18 F)-labeled stilbene derivative that was developed
as a positron emission tomography (PET) tracer for routine clinical application to visualize β …
as a positron emission tomography (PET) tracer for routine clinical application to visualize β …
[HTML][HTML] Aβ plaques
LC Walker - Free neuropathology, 2020 - ncbi.nlm.nih.gov
Aβ plaques are one of the two lesions in the brain that define the neuropathological
diagnosis of Alzheimer's disease. Plaques are highly diverse structures; many of them …
diagnosis of Alzheimer's disease. Plaques are highly diverse structures; many of them …