Non-invasive molecular imaging of kidney diseases

BM Klinkhammer, T Lammers, FM Mottaghy… - Nature Reviews …, 2021 - nature.com
In nephrology, differential diagnosis or assessment of disease activity largely relies on the
analysis of glomerular filtration rate, urinary sediment, proteinuria and tissue obtained …

Radionuclides in nephrourology, part 1: Radiopharmaceuticals, quality control, and quantitative indices

AT Taylor - Journal of Nuclear Medicine, 2014 - Soc Nuclear Med
Radionuclide renal scintigraphy provides important functional data to assist in the diagnosis
and management of patients with a variety of suspected genitourinary tract problems, but the …

[HTML][HTML] Structural and functional NIR-II fluorescence bioimaging in urinary system via clinically approved dye methylene blue

D Xue, D Wu, Z Lu, J Neuhaus, A Zebibula, Z Feng… - Engineering, 2023 - Elsevier
Accurate structural and functional imaging is vital for the diagnosis and prognosis of urinary
system diseases. Fluorescence bioimaging in the second near-infrared spectral region (NIR …

Multifunctional Cyclopentadienes as a Scaffold for Combinatorial Bioorganometallics in [(η5‐C5H2R1R2R3)M(CO)3] (M=Re, 99mTc) Piano‐Stool Complexes

A Frei, B Spingler, R Alberto - Chemistry–A European Journal, 2018 - Wiley Online Library
Multifunctional cyclopentadiene (Cp) ligands and their rhenium and 99mTc complexes were
prepared by a versatile synthetic route. The properties of these Cp ligands can be tuned on …

Re (CO) 3 ([18F] FEDA), a novel 18F PET renal tracer: radiosynthesis and preclinical evaluation

M Lipowska, N Jarkas, RJ Voll, JA Nye, J Klenc… - Nuclear medicine and …, 2018 - Elsevier
Introduction Our previous work demonstrated that the 99m Tc renal tracer, 99m Tc (CO) 3
(FEDA)(99m Tc-1), has a rapid clearance comparable in rats to that of 131 I-OIH, the …

fac-99mTc/Re-tricarbonyl complexes with tridentate aminocarboxyphosphonate ligands: Suitability of the phosphonate group in chelate ligand design of new imaging …

M Lipowska, J Klenc, AT Taylor, LG Marzilli - Inorganica chimica acta, 2019 - Elsevier
Ligands that coordinate via dianionic phosphonate groups have not been widely utilized in
radiopharmaceuticals. N-(phosphonomethyl) iminodiacetic acid (1, PMIDA) and N …

Kinetics and Mechanism of CO Exchange in fac-[MBr2(solvent)(CO)3] (M = Re, 99Tc)

A Frei, D Sidler, P Mokolokolo, H Braband… - Inorganic …, 2016 - ACS Publications
The self-exchange kinetics of CO ligands in the solvated forms of the commonly used
complex [MBr3 (CO) 3] 2–(M= Re, 99Tc) were investigated in-depth by 13C NMR …

Complexes Possessing Rare “Tertiary” Sulfonamide Nitrogen-to-Metal Bonds of Normal Length: fac-[Re(CO)3(N(SO2R)dien)]PF6 Complexes with Hydrophilic …

PL Abhayawardhana, PA Marzilli, FR Fronczek… - Inorganic …, 2014 - ACS Publications
Tertiary sulfonamide nitrogen-to-metal bonds of normal length are very rare. We recently
discovered such a bond in one class of fac-[Re (CO) 3 (N (SO2R)(CH2Z) 2)] n complexes …

Al18F-NODA-butyric acid: biological evaluation of a new PET renal radiotracer

M Lipowska, J Klenc, D Shetty, JA Nye, H Shim… - Nuclear medicine and …, 2014 - Elsevier
Introduction Renal scintigraphy is an important imaging modality for the diagnosis and
management of a variety of renal diseases including obstruction and renovascular …

Monoanionic 99mTc-tricarbonyl-aminopolycarboxylate complexes with uncharged pendant groups: radiosynthesis and evaluation as potential renal tubular tracers

M Lipowska, J Klenc, N Jarkas, LG Marzilli… - Nuclear medicine and …, 2017 - Elsevier
Abstract Introduction 99m Tc (CO) 3-nitrilotriacetic acid, 99m Tc (CO) 3 (NTA), is a new renal
tubular agent with pharmacokinetic properties comparable to those of 131 I-OIH but the …