Positron emission tomography (PET) is a radiotracer imaging method that yields quantitative
images of regional in vivo biology and biochemistry. PET, now used in conjunction with …

Complex molecular and metabolic phenotypes depict cancers as a constellation of different
diseases with common themes. Precision imaging of such phenotypes requires flexible and …

Since their discovery as distinct receptor proteins, the specific physiopathological role of
sigma receptors (σRs) has been deeply investigated. It has been reported that these …

CRISPR/Cas gene studies were conducted in HeLa cells where either PGRMC1, TMEM97
or both proteins were removed via gene editing. A series of radioligand binding studies …

Rationale: Idiopathic pulmonary fibrosis (IPF) is a progressive inflammatory lung disease
without effective molecular markers of disease activity or treatment responses. Monocyte …

Sigma receptors (sigma-1 and sigma-2) represent two independent classes of proteins.
Their endogenous ligands may include the hallucinogen N, N-dimethyltryptamine (DMT) …

For the purpose of this review, active targeting in cancer research encompasses strategies
wherein a ligand for a cell surface receptor expressed on tumor cells is used to deliver a …

The σ2 receptor is an important target for the development of molecular probes in oncology
because of its 10-fold higher density in proliferating tumor cells compared with that in …

The sigma‐2 receptor is highly expressed in various rapidly proliferating cancer cells and
regarded as a cancer cell biomarker. Selective sigma‐2 ligands have been shown to …

The sigma-2 receptor was originally defined pharmacologically and recently identified as
TMEM97. TMEM97 has been validated as a biomarker of proliferative status and the …