Tumor hypoxia is a well-established biological phenomenon that affects the curability of
solid tumors, regardless of treatment modality. Especially for head and neck cancer patients …

Since the initial observations made at the beginning of the last century, it has been
established that solid tumors contain regions of low oxygenation (hypoxia). Tumor cells can …

Local hypoxia in tumors is an undesirable consequence of photodynamic therapy (PDT),
which will lead to greatly reduced effectiveness of this therapy. Bioreductive pro‐drugs that …

Hypoxia, a hallmark of most solid tumours, is a negative prognostic factor due to its
association with an aggressive tumour phenotype and therapeutic resistance. Given its …

Over the last few years, cancer immunotherapy experienced tremendous developments and
it is nowadays considered a promising strategy against many types of cancer. However, the …

Hypoxia is a pathological condition arising in living tissues when oxygen supply does not
adequately cover the cellular metabolic demand. Detection of this phenomenon in tumors is …

Tumour hypoxia is a known and extensively researched phenomenon that occurs in both
solid and haematological malignancies. As cancer cells proliferate, demand for oxygen can …

Purpose Hypoxia is a condition of insufficient oxygen to support metabolism which occurs
when the vascular supply is interrupted, or when a tumour outgrows its vascular supply. It is …

Hypoxia was identified as a microenvironmental component of solid tumours over 60 years
ago and was immediately recognised as a potential barrier to therapy through the reliance of …

Purpose Several individual clinical and preclinical studies have shown the possibility of
evaluating tumor hypoxia by using noninvasive positron emission tomography (PET). The …