Hypoglycemia is the most frequent complication of insulin therapy in patients with type 1
diabetes. Since the brain is reliant on circulating glucose as its main source of energy …

Hypoglycemia is a serious complication of insulin treatment of diabetes that can lead to
coma and death. Neurovascular coupling, which mediates increased local blood flow in …

Diabetes is a chronic non-communicable disease affecting over 400 million people
worldwide. Diabetic patients are at a high risk of various complications, such as …

Small-animal imaging has become an important technique for the development of new
radiotracers, drugs and therapies. Many laboratories have now a combination of different …

Functional connectivity of blood oxygenation level dependent signal fluctuations (BOLD-FC)
is decreased in Alzheimer's disease (AD), and suggested to reflect reduced coherence in …

Background Kinetic modelling of dynamic PET typically requires knowledge of the arterial
radiotracer concentration (arterial input function, AIF). Its accurate determination is very …

The kinetics of permeation across epithelial and endothelial cell sheets and across cell
membranes is determinant for the pharmacokinetics of a drug. In vitro transport experiments …

Although numerous positron emission tomography (PET) studies with 18F‐fluoro‐
deoxyglucose (FDG) have reported quantitative results on cerebral glucose kinetics and …

Introduction The use of the same imaging and quantification techniques in small animals
and clinical studies presents the opportunity for direct translational research in drug …

BACKGROUND: Hypoglycemia occurs frequently in the neonate and may result in
neurologic dysfunction. Its impact on the kinetics of cellular respiration and bioenergetics in …