[HTML][HTML] The clinical impact of glycobiology: targeting selectins, Siglecs and mammalian glycans
BAH Smith, CR Bertozzi - Nature reviews Drug discovery, 2021 - nature.com
Carbohydrates—namely glycans—decorate every cell in the human body and most secreted
proteins. Advances in genomics, glycoproteomics and tools from chemical biology have …
proteins. Advances in genomics, glycoproteomics and tools from chemical biology have …
ImmunoPET: concept, design, and applications
W Wei, ZT Rosenkrans, J Liu, G Huang, QY Luo… - Chemical …, 2020 - ACS Publications
Immuno-positron emission tomography (immunoPET) is a paradigm-shifting molecular
imaging modality combining the superior targeting specificity of monoclonal antibody (mAb) …
imaging modality combining the superior targeting specificity of monoclonal antibody (mAb) …
Roles of CA19-9 in pancreatic cancer: Biomarker, predictor and promoter
G Luo, K Jin, S Deng, H Cheng, Z Fan, Y Gong… - … et Biophysica Acta (BBA …, 2021 - Elsevier
Abstract Carbohydrate antigen 19-9 (CA19-9) is the best validated biomarker and an
indicator of aberrant glycosylation in pancreatic cancer. CA19-9 functions as a biomarker …
indicator of aberrant glycosylation in pancreatic cancer. CA19-9 functions as a biomarker …
Future of theranostics: an outlook on precision oncology in nuclear medicine
T Langbein, WA Weber, M Eiber - Journal of Nuclear Medicine, 2019 - Soc Nuclear Med
Molecular alterations in malignant disease result in the expression or upregulations of
various targets that can be used for imaging and treatment with radiopharmaceuticals. This …
various targets that can be used for imaging and treatment with radiopharmaceuticals. This …
The glycan CA19-9 promotes pancreatitis and pancreatic cancer in mice
Glycosylation alterations are indicative of tissue inflammation and neoplasia, but whether
these alterations contribute to disease pathogenesis is largely unknown. To study the role of …
these alterations contribute to disease pathogenesis is largely unknown. To study the role of …
[HTML][HTML] Low-dose radiation conditioning enables CAR T cells to mitigate antigen escape
CD19 chimeric antigen receptors (CARs) have demonstrated great efficacy against a range
of B cell malignancies. However, antigen escape and more generally heterogeneous …
of B cell malignancies. However, antigen escape and more generally heterogeneous …
Alternative Chelator for 89Zr Radiopharmaceuticals: Radiolabeling and Evaluation of 3,4,3-(LI-1,2-HOPO)
Zirconium-89 is an effective radionuclide for antibody-based positron emission tomography
(PET) imaging because its physical half-life (78.41 h) matches the biological half-life of IgG …
(PET) imaging because its physical half-life (78.41 h) matches the biological half-life of IgG …
p-SCN-Bn-HOPO: A Superior Bifunctional Chelator for 89Zr ImmunoPET
MA Deri, S Ponnala, P Kozlowski… - Bioconjugate …, 2015 - ACS Publications
Zirconium-89 has an ideal half-life for use in antibody-based PET imaging; however, when
used with the chelator DFO, there is an accumulation of radioactivity in the bone, suggesting …
used with the chelator DFO, there is an accumulation of radioactivity in the bone, suggesting …
18F-Based Pretargeted PET Imaging Based on Bioorthogonal Diels–Alder Click Chemistry
JP Meyer, JL Houghton, P Kozlowski… - Bioconjugate …, 2016 - ACS Publications
A first-of-its-kind 18F pretargeted PET imaging approach based on the bioorthogonal
inverse electron demand Diels–Alder (IEDDA) reaction between tetrazine (Tz) and trans …
inverse electron demand Diels–Alder (IEDDA) reaction between tetrazine (Tz) and trans …
[HTML][HTML] ImmunoPET: antibody-based PET imaging in solid tumors
R Manafi-Farid, B Ataeinia, S Ranjbar… - Frontiers in …, 2022 - frontiersin.org
Immuno-positron emission tomography (immunoPET) is a molecular imaging modality
combining the high sensitivity of PET with the specific targeting ability of monoclonal …
combining the high sensitivity of PET with the specific targeting ability of monoclonal …