The development of reversibly binding radioligands for imaging brain proteins in vivo, such
as enzymes, neurotransmitter transporters, receptors and ion channels, with positron …

Objective: The purpose of this study was to determine whether microglial activity, measured
using translocator-protein positron emission tomography (PET) imaging, is increased in …

Alzheimer's disease is characterized by the histopathological presence of amyloid-β
plaques and tau-containing neurofibrillary tangles. Microglial activation is also a recognized …

Non-invasive positron emission tomography (PET) and single-photon emission computed
tomography (SPECT) are techniques used to quantify molecular interactions, biological …

The positron emission tomography radioligand [11C] PBR28 targets translocator protein (18
kDa)(TSPO) and is a potential marker of neuroinflammation.[11C] PBR28 binding is …

Objective Surgery launches a systemic inflammatory reaction that reaches the brain and
associates with immune activation and cognitive decline. Although preclinical studies have …

Converging evidence points to the significant involvement of the immune system in autism
spectrum disorders (ASD). Positron emission tomography (PET) can quantify translocator …

A role for immunological involvement in autism spectrum disorder (ASD) has long been
hypothesized. This review includes four sections describing (1) evidence for a relationship …

Purpose TSPO PET imaging may hold promise as a single-step diagnostic work-up for
clinical immunopsychiatry. This review paper on the clinical applicability of TSPO PET for …

Several lines of evidence implicate microglial activation and abnormal immune response in
the etiology of psychosis. Previous positron emission tomography (PET) neuroimaging …