Integrins are considered the main cell-adhesion transmembrane receptors that play
multifaceted roles as extracellular matrix (ECM)-cytoskeletal linkers and transducers in …

Positron emission tomography (PET) uses radioactive tracers and enables the functional
imaging of several metabolic processes, blood flow measurements, regional chemical …

The surface of a cell represents a collection of macromolecules, which provides the cell with
a unique cellular landscape specific to the type and state of the cell. Ligands that …

18F-FPPRGD2, which was approved for clinical study recently, has favorable properties for
integrin targeting and showed potential for antiangiogenic therapy and early response …

Peptide-based strategies have received an enormous amount of attention because of their
specificity and applicability. Their specificity and tumor-targeting ability are applied to …

To maximize tumor excision and minimize collateral damage are the primary goals of cancer
surgery. Emerging molecular imaging techniques have made “image-guided surgery” …

Angiogenesis is a requirement for tumor growth and metastasis. The angiogenic process
depends on vascular endothelial cell migration and invasion, and is regulated by various …

Molecular radiopharmaceuticals based on bioconjugates of chelators with peptides and
proteins have had significant clinical impact in the diagnosis and treatment of several types …

One of the main reasons why most cancer patients do not respond well to chemotherapy is
that drugs cannot accumulate in tumors at an optimal dose, eventually resulting in failure to …

Following injurious stimuli, quiescent hepatic stellate cells (qHSCs) transdifferentiate into
activated HSCs (aHSCs). aHSCs play pivotal roles in the onset and progression of liver …