Molecular imaging of the cardiac extracellular matrix
In almost all cardiac diseases, an increase in extracellular matrix (ECM) deposition or
fibrosis occurs, mostly consisting of collagen I. Whereas replacement fibrosis follows …
fibrosis occurs, mostly consisting of collagen I. Whereas replacement fibrosis follows …
[HTML][HTML] Harnessing extracellular matrix biology for tumor drug delivery
N Subrahmanyam, H Ghandehari - Journal of Personalized Medicine, 2021 - mdpi.com
The extracellular matrix (ECM) plays an active role in cell life through a tightly controlled
reciprocal relationship maintained by several fibrous proteins, enzymes, receptors, and …
reciprocal relationship maintained by several fibrous proteins, enzymes, receptors, and …
[HTML][HTML] Colorful protein-based fluorescent probes for collagen imaging
SJA Aper, ACC van Spreeuwel, MC van Turnhout… - PloS one, 2014 - journals.plos.org
Real-time visualization of collagen is important in studies on tissue formation and
remodeling in the research fields of developmental biology and tissue engineering. Our …
remodeling in the research fields of developmental biology and tissue engineering. Our …
Collagen-Targeting Self-Assembled Nanoprobes for Multimodal Molecular Imaging and Quantification of Myocardial Fibrosis in a Rat Model of Myocardial Infarction
F Li, L Chen, S Zhong, J Chen, Y Cao, H Yu, H Ran… - ACS …, 2024 - ACS Publications
Currently, inadequate early diagnostic methods hinder the prompt treatment of patients with
heart failure and myocardial fibrosis. Magnetic resonance imaging is the gold standard …
heart failure and myocardial fibrosis. Magnetic resonance imaging is the gold standard …
[HTML][HTML] Optimising the radiolabelling properties of technetium tricarbonyl and His-tagged proteins
A Badar, J Williams, RTM de Rosales, R Tavaré… - EJNMMI research, 2014 - Springer
Background To date, the majority of protein-based radiopharmaceuticals have been
radiolabelled using non-site-specific conjugation methods, with little or no control to ensure …
radiolabelled using non-site-specific conjugation methods, with little or no control to ensure …
Construction of CNA35 collagen-targeted phase-changeable nanoagents for low-intensity focused ultrasound-triggered ultrasound molecular imaging of myocardial …
Q Zhou, Y Zeng, Q Xiong, S Zhong, P Li… - … applied materials & …, 2019 - ACS Publications
Myocardial fibrosis plays an important role in the development of heart failure and malignant
arrhythmia, which potentially increases the incidence of sudden cardiac death. Therefore …
arrhythmia, which potentially increases the incidence of sudden cardiac death. Therefore …
Nondestructive monitoring of tissue-engineered constructs
J Frese, A Morgenroth, ME Mertens, S Koch… - Biomedical …, 2014 - degruyter.com
Tissue engineering as a multidisciplinary field enables the development of living substitutes
to replace, maintain, or restore diseased tissue and organs. Since the term was introduced …
to replace, maintain, or restore diseased tissue and organs. Since the term was introduced …
A novel multivalent 99mTc-labeled EG2-C4bpα antibody for targeting the epidermal growth factor receptor in tumor xenografts
Introduction The C4b binding protein (C4bp) α/β-chain C-terminal effectively induces
polymerization during protein synthesis. Using this fragment and the single-domain antibody …
polymerization during protein synthesis. Using this fragment and the single-domain antibody …
Ex vivo and in vivo administration of fluorescent CNA35 specifically marks cardiac fibrosis
S de Jong, LB van Middendorp… - Molecular …, 2014 - journals.sagepub.com
Cardiac fibrosis is a major hallmark of cardiac diseases. For evaluation of cardiac fibrosis,
the development of highly specific and preferably noninvasive methods is desired. Our aim …
the development of highly specific and preferably noninvasive methods is desired. Our aim …
Radiolabeled imaging probes targeting angiogenesis for personalized medicine
S YA Terry, M Rijpkema, K Abiraj… - Current …, 2014 - ingentaconnect.com
Angiogenesis is essential for tumor growth and inhibiting angiogenesis has become an
important therapeutic strategy in clinical oncology. Nonetheless, the mechanisms behind …
important therapeutic strategy in clinical oncology. Nonetheless, the mechanisms behind …