Molecular imaging of the cardiac extracellular matrix

HJ de Haas, E Arbustini, V Fuster, CM Kramer… - Circulation …, 2014 - Am Heart Assoc
In almost all cardiac diseases, an increase in extracellular matrix (ECM) deposition or
fibrosis occurs, mostly consisting of collagen I. Whereas replacement fibrosis follows …

[HTML][HTML] Harnessing extracellular matrix biology for tumor drug delivery

N Subrahmanyam, H Ghandehari - Journal of Personalized Medicine, 2021 - mdpi.com
The extracellular matrix (ECM) plays an active role in cell life through a tightly controlled
reciprocal relationship maintained by several fibrous proteins, enzymes, receptors, and …

[HTML][HTML] Colorful protein-based fluorescent probes for collagen imaging

SJA Aper, ACC van Spreeuwel, MC van Turnhout… - PloS one, 2014 - journals.plos.org
Real-time visualization of collagen is important in studies on tissue formation and
remodeling in the research fields of developmental biology and tissue engineering. Our …

Collagen-Targeting Self-Assembled Nanoprobes for Multimodal Molecular Imaging and Quantification of Myocardial Fibrosis in a Rat Model of Myocardial Infarction

F Li, L Chen, S Zhong, J Chen, Y Cao, H Yu, H Ran… - ACS …, 2024 - ACS Publications
Currently, inadequate early diagnostic methods hinder the prompt treatment of patients with
heart failure and myocardial fibrosis. Magnetic resonance imaging is the gold standard …

[HTML][HTML] Optimising the radiolabelling properties of technetium tricarbonyl and His-tagged proteins

A Badar, J Williams, RTM de Rosales, R Tavaré… - EJNMMI research, 2014 - Springer
Background To date, the majority of protein-based radiopharmaceuticals have been
radiolabelled using non-site-specific conjugation methods, with little or no control to ensure …

Construction of CNA35 collagen-targeted phase-changeable nanoagents for low-intensity focused ultrasound-triggered ultrasound molecular imaging of myocardial …

Q Zhou, Y Zeng, Q Xiong, S Zhong, P Li… - … applied materials & …, 2019 - ACS Publications
Myocardial fibrosis plays an important role in the development of heart failure and malignant
arrhythmia, which potentially increases the incidence of sudden cardiac death. Therefore …

Nondestructive monitoring of tissue-engineered constructs

J Frese, A Morgenroth, ME Mertens, S Koch… - Biomedical …, 2014 - degruyter.com
Tissue engineering as a multidisciplinary field enables the development of living substitutes
to replace, maintain, or restore diseased tissue and organs. Since the term was introduced …

A novel multivalent 99mTc-labeled EG2-C4bpα antibody for targeting the epidermal growth factor receptor in tumor xenografts

C Li, Y Zhang, L Wang, H Feng, X Xia, J Ma… - Nuclear Medicine and …, 2015 - Elsevier
Introduction The C4b binding protein (C4bp) α/β-chain C-terminal effectively induces
polymerization during protein synthesis. Using this fragment and the single-domain antibody …

Ex vivo and in vivo administration of fluorescent CNA35 specifically marks cardiac fibrosis

S de Jong, LB van Middendorp… - Molecular …, 2014 - journals.sagepub.com
Cardiac fibrosis is a major hallmark of cardiac diseases. For evaluation of cardiac fibrosis,
the development of highly specific and preferably noninvasive methods is desired. Our aim …

Radiolabeled imaging probes targeting angiogenesis for personalized medicine

S YA Terry, M Rijpkema, K Abiraj… - Current …, 2014 - ingentaconnect.com
Angiogenesis is essential for tumor growth and inhibiting angiogenesis has become an
important therapeutic strategy in clinical oncology. Nonetheless, the mechanisms behind …