[HTML][HTML] Recent developments on PET radiotracers for TSPO and their applications in neuroimaging
The 18 kDa translocator protein (TSPO), previously known as the peripheral
benzodiazepine receptor, is predominately localized to the outer mitochondrial membrane in …
benzodiazepine receptor, is predominately localized to the outer mitochondrial membrane in …
[HTML][HTML] VDAC1 and the TSPO: expression, interactions, and associated functions in health and disease states
V Shoshan-Barmatz, S Pittala, D Mizrachi - International journal of …, 2019 - mdpi.com
The translocator protein (TSPO), located at the outer mitochondrial membrane (OMM),
serves multiple functions and contributes to numerous processes, including cholesterol …
serves multiple functions and contributes to numerous processes, including cholesterol …
[HTML][HTML] Microglial activation mediates chronic mild stress-induced depressive-and anxiety-like behavior in adult rats
YL Wang, QQ Han, WQ Gong, DH Pan… - Journal of …, 2018 - Springer
Background Depression is a heterogeneous disorder, with the exact neuronal mechanisms
causing the disease yet to be discovered. Recent work suggests it is accompanied by neuro …
causing the disease yet to be discovered. Recent work suggests it is accompanied by neuro …
Recent progress in the development of TSPO PET ligands for neuroinflammation imaging in neurological diseases
MM Alam, J Lee, SY Lee - Nuclear medicine and molecular imaging, 2017 - Springer
Neuroinflammation is heavily associated with various neurological diseases including
Alzheimer's disease, Parkinson's disease, multiple sclerosis, and stroke. It is strongly …
Alzheimer's disease, Parkinson's disease, multiple sclerosis, and stroke. It is strongly …
[HTML][HTML] Novel PET imaging of inflammatory targets and cells for the diagnosis and monitoring of giant cell arteritis and polymyalgia rheumatica
Giant cell arteritis (GCA) and polymyalgia rheumatica (PMR) are two interrelated
inflammatory diseases affecting patients above 50 years of age. Patients with GCA suffer …
inflammatory diseases affecting patients above 50 years of age. Patients with GCA suffer …
In vivo detection of age-and disease-related increases in neuroinflammation by 18F-GE180 TSPO microPET imaging in wild-type and Alzheimer's transgenic mice
B Liu, KX Le, MA Park, S Wang… - Journal of …, 2015 - Soc Neuroscience
Alzheimer's disease (AD) is the most common cause of dementia. Neuroinflammation
appears to play an important role in AD pathogenesis. Ligands of the 18 kDa translocator …
appears to play an important role in AD pathogenesis. Ligands of the 18 kDa translocator …
[HTML][HTML] Glia and immune cell signaling in bipolar disorder: insights from neuropharmacology and molecular imaging to clinical application
CC Watkins, A Sawa, MG Pomper - Translational psychiatry, 2014 - nature.com
Bipolar disorder (BD) is a debilitating mental illness characterized by severe fluctuations in
mood, sleep, energy and executive functioning. Pharmacological studies of selective …
mood, sleep, energy and executive functioning. Pharmacological studies of selective …
Regional brain distribution of translocator protein using [11C]DPA-713 PET in individuals infected with HIV
Imaging the brain distribution of translocator protein (TSPO), a putative biomarker for glial
cell activation and neuroinflammation, may inform management of individuals infected with …
cell activation and neuroinflammation, may inform management of individuals infected with …
[HTML][HTML] Radiosynthesis and characterization of [18F]BS224: a next-generation TSPO PET ligand insensitive to the rs6971 polymorphism
SH Lee, N Denora, V Laquintana… - European Journal of …, 2021 - Springer
Abstract Purpose Translocator protein 18-kDa (TSPO) positron emission tomography (PET)
is a valuable tool to detect neuroinflammed areas in a broad spectrum of neurodegenerative …
is a valuable tool to detect neuroinflammed areas in a broad spectrum of neurodegenerative …
Noninvasive molecular imaging of tuberculosis-associated inflammation with radioiodinated DPA-713
CA Foss, JS Harper, H Wang… - The Journal of …, 2013 - academic.oup.com
Background. Increased expression of translocator protein (TSPO) is a feature of microglial
and macrophage activation. Since activated macrophages are key components of …
and macrophage activation. Since activated macrophages are key components of …