The ongoing search for therapeutic interventions in Alzheimer disease (AD) has highlighted
the complexity of this condition and the need for additional biomarkers, beyond amyloid-β …

Progress in the fields of neuroscience and molecular biology has identified the forebrain
cholinergic system as being important in many higher order brain functions. Further analysis …

The positron emission tomography (PET) molecular imaging technique has gained its
universal value as a remarkable tool for medical diagnosis and biomedical research …

Amyloid-β (Aβ) accumulation and tauopathy are considered the pathological hallmarks of
Alzheimer's disease (AD), but attenuation in choline signaling, including decreased nicotinic …

Background The α7 nicotinic acetylcholine receptor increasingly has been implicated in
normal brain physiology, as well as in neuropsychiatric disorders. The highly cortical …

Purpose Using the α7-nAChR radiotracer,[18 F] ASEM, we present the first successful
human positron emission tomography (PET) studies. Rodent occupancy with three clinically …

The inflammatory response is a major factor in stroke pathophysiology and contributes to
secondary neuronal damage in both acute and chronic stages of the ischemic injury. Recent …

Purpose The α 7 nicotinic acetylcholine receptor (nAChR) is implicated in many
neuropsychiatric disorders, making it an important target for positron emission tomography …

Cholinergic receptors represent a promising class of diagnostic and therapeutic targets due
to their significant involvement in cognitive decline associated with neurological disorders …

Positron emission tomography (PET) is useful for noninvasive in vivo visualization of
disease-related receptors, for evaluation of receptor occupancy to determine an appropriate …