New frontiers in the design and synthesis of imaging probes for PET oncology: current challenges and future directions
G Smith, L Carroll, EO Aboagye - Molecular imaging and biology, 2012 - Springer
Despite being developed over 30 years ago, 2-deoxy-2-[18 F] fluoro-d-glucose remains the
most frequently used radiotracer in PET oncology. In the last decade, interest in new and …
most frequently used radiotracer in PET oncology. In the last decade, interest in new and …
High-throughput screening with nanoimprinting 3D culture for efficient drug development by mimicking the tumor environment
Y Yoshii, T Furukawa, A Waki, H Okuyama, M Inoue… - Biomaterials, 2015 - Elsevier
Anti-cancer drug development typically utilizes high-throughput screening with two-
dimensional (2D) cell culture. However, 2D culture induces cellular characteristics different …
dimensional (2D) cell culture. However, 2D culture induces cellular characteristics different …
[HTML][HTML] Comparison of 11C-4′-thiothymidine, 11C-methionine, and 18F-FDG PET/CT for the detection of active lesions of multiple myeloma
M Okasaki, K Kubota, R Minamimoto, Y Miyata… - Annals of nuclear …, 2015 - Springer
Purpose The aims of this study were to evaluate the possibility of using 11 C-methionine (11
C-MET) and 11 C-4′-thiothymidine (11 C-4DST) whole-body PET/CT for the imaging of …
C-MET) and 11 C-4′-thiothymidine (11 C-4DST) whole-body PET/CT for the imaging of …
Direct comparison of radiation dosimetry of six PET tracers using human whole-body imaging and murine biodistribution studies
M Sakata, K Oda, J Toyohara, K Ishii, T Nariai… - Annals of nuclear …, 2013 - Springer
Objective We investigated the whole-body biodistributions and radiation dosimetry of five 11
C-labeled and one 18 F-labeled radiotracers in human subjects, and compared the results …
C-labeled and one 18 F-labeled radiotracers in human subjects, and compared the results …
4′-[Methyl-11C]-Thiothymidine PET/CT for Proliferation Imaging in Non–Small Cell Lung Cancer
R Minamimoto, J Toyohara, A Seike, H Ito… - Journal of Nuclear …, 2012 - Soc Nuclear Med
A new tracer, 4′-[methyl-11C]-thiothymidine (11C-4DST), has been developed as an in
vivo cell proliferation marker based on the DNA incorporation method. This study evaluated …
vivo cell proliferation marker based on the DNA incorporation method. This study evaluated …
[HTML][HTML] 18F-FDG and 11C-4DST PET/CT for evaluating response to platinum-based doublet chemotherapy in advanced non-small cell lung cancer: a prospective …
R Minamimoto, Y Takeda, M Hotta, J Toyohara… - EJNMMI research, 2019 - Springer
Abstract Background 4′-[Methyl-11 C] thiothymidine (4DST) PET/CT provides DNA
synthesis imaging, which represented a higher correlation with the proliferation in advanced …
synthesis imaging, which represented a higher correlation with the proliferation in advanced …
[HTML][HTML] A pilot study of 4′-[methyl-11C]-thiothymidine PET/CT for detection of regional lymph node metastasis in non-small cell lung cancer
R Minamimoto, J Toyohara, H Ito, A Seike, Y Miyata… - EJNMMI research, 2014 - Springer
Abstract Background 4′-[methyl-11 C]-thiothymidine (4DST) is a novel positron emission
tomography (PET) tracer to assess proliferation of malignancy. The diagnostic abilities of …
tomography (PET) tracer to assess proliferation of malignancy. The diagnostic abilities of …
Correlation of 4′-[methyl-11 C]-thiothymidine uptake with Ki-67 immunohistochemistry and tumor grade in patients with newly diagnosed gliomas in comparison with …
K Tanaka, Y Yamamoto, Y Maeda, H Yamamoto… - Annals of nuclear …, 2016 - Springer
Abstract Objective A novel radiopharmaceutical, 4′-[methyl-11 C] thiothymidine (11 C-
4DST), has been developed as an in vivo cell proliferation marker based on the DNA …
4DST), has been developed as an in vivo cell proliferation marker based on the DNA …
[HTML][HTML] Efficacy of 4′-[methyl-11C] thiothymidine PET/CT before and after neoadjuvant therapy for predicting therapeutic responses in patients with esophageal …
M Hotta, R Minamimoto, K Yamada, K Nohara… - EJNMMI research, 2019 - Springer
Abstract Background 4′-[Methyl-11C] thiothymidine (4DST) has been introduced as a new
cell proliferation imaging PET tracer that incorporates into DNA directly. The aim of this …
cell proliferation imaging PET tracer that incorporates into DNA directly. The aim of this …
[HTML][HTML] Amino Acid and Proliferation PET/CT for the Diagnosis of Multiple Myeloma
R Minamimoto - Frontiers in Nuclear Medicine, 2022 - frontiersin.org
Multiple myeloma (MM) is a hematologic malignancy characterized by infiltration of
monoclonal plasma cells in the bone marrow (BM). The standard examination performed for …
monoclonal plasma cells in the bone marrow (BM). The standard examination performed for …