The International Commission on Radiation Units and Measurements (ICRU), since its
inception in 1925, has had as its principal objective the development of internationally …

Patients undergoing nuclear medicine procedures for cancer therapy are administered
radiopharmaceuticals that emit various types of radiation. Because radiation has differential …

Radiopharmaceutical therapy is growing rapidly. However, yet to be addressed is the
implementation of methods to plan treatments for circulating tumor cells, disseminated tumor …

In oncology, the holy grail of radiotherapy is specific radiation dose deposition in tumours
with minimal healthy tissue toxicity. If used appropriately, injectable, systemic radionuclide …

The spatial distribution of radiopharmaceuticals that emit short-range high linear-energy-
transfer electrons greatly affects absorbed dose and biological effectiveness. The purpose of …

Current preclinical dosimetric models often fail to take account of the complex nature of
absorbed dose distribution typical of in vitro clonogenic experiments in targeted radionuclide …

Rationale The role of radiation-induced bystander effects in cancer therapy with alpha-
particle emitting radiopharmaceuticals remains unclear. With renewed interest in using …

Purpose: Based on the authors' previous findings concerning the radiotoxicity of99mTc, the
authors compared the cellular survival under the influence of this nuclide with that following …

The distribution of radiopharmaceuticals in tumor cells represents a fundamental aspect for
a successful molecular targeted radiotherapy. It was largely demonstrated at microscopic …

Purpose: The biological response of tissue exposed to radiations emitted by internal
radioactivity is often correlated with the mean absorbed dose to a tissue element. However …