Immuno-positron emission tomography (immunoPET) is a paradigm-shifting molecular
imaging modality combining the superior targeting specificity of monoclonal antibody (mAb) …

In nephrology, differential diagnosis or assessment of disease activity largely relies on the
analysis of glomerular filtration rate, urinary sediment, proteinuria and tissue obtained …

Identification of cancer cell–surface biomarkers and advances in antibody engineering have
led to a sharp increase in the development of therapeutic antibodies. These same advances …

Immuno-positron emission tomography (immunoPET) is a molecular imaging modality
combining the high sensitivity of PET with the specific targeting ability of monoclonal …

Tumor microenvironment substantially influences the process of tumorigenesis. In many
solid tumors, imbalance between the demand of rapidly proliferating cancer cells and the …

Target-specific biomolecules, monoclonal antibodies (mAb), proteins, and protein fragments
are known to have high specificity and affinity for receptors associated with tumors and other …

Positron emission tomography (PET) is used extensively in clinical oncology for tumor
detection, staging and therapy response assessment. Quantitative measurements of tumor …

Until recently, iodine-124 was not considered to be an attractive isotope for medical
applications owing to its complex radioactive decay scheme, which includes several high …

Abstract Radioimmunotherapy (RIT) with 131I-labeled L19SIP (radretumab; a small
immunoprotein format antibody directed against the ED-B domain of fibronectin;∼ 80 kDa …

Targeted therapies, including antibodies, are becoming increasingly important in cancer
therapy. Important limitations, however, are that not every patient benefits from a specific …