[HTML][HTML] Stem cell-based human blood–brain barrier models for drug discovery and delivery
S Aday, R Cecchelli, D Hallier-Vanuxeem… - Trends in …, 2016 - cell.com
The development of novel neuropharmaceuticals requires the evaluation of blood–brain
barrier (BBB) permeability and toxicity. Recent studies have highlighted differences in the …
barrier (BBB) permeability and toxicity. Recent studies have highlighted differences in the …
[HTML][HTML] Essential principles and recent progress in the development of TSPO PET ligands for neuroinflammation imaging
M Viviano, E Barresi, FG Siméon, B Costa… - Current medicinal …, 2022 - ncbi.nlm.nih.gov
The translocator protein 18kDa (TSPO) is expressed in the outer mitochondrial membrane
and is implicated in several functions, including cholesterol transport and steroidogenesis …
and is implicated in several functions, including cholesterol transport and steroidogenesis …
Overlapping substrate and inhibitor specificity of human and murine ABCG2
ABCG2 (also known as breast cancer resistance protein) is an ATP-binding cassette (ABC)
transporter localized to the plasma membrane where it mediates the efflux of xenobiotics …
transporter localized to the plasma membrane where it mediates the efflux of xenobiotics …
Effect of structural modifications to glyoxal-bis (thiosemicarbazonato) copper (II) complexes on cellular copper uptake, copper-mediated ATP7A trafficking, and P …
KM Acevedo, DJ Hayne, LE McInnes… - Journal of medicinal …, 2018 - ACS Publications
Bis (thiosemicarbazonato) copper (II) complexes are of interest as potential therapeutics for
cancer and neurodegenerative diseases as well as imaging agents for positron emission …
cancer and neurodegenerative diseases as well as imaging agents for positron emission …
Discrepancies in the P-glycoprotein-Mediated Transport of 18F-MPPF: A Pharmacokinetic Study in Mice and Non-human Primates
N Tournier, S Cisternino, MA Peyronneau… - Pharmaceutical …, 2012 - Springer
Purpose Several in vivo studies have found that the 5-HT 1A PET radioligand 18 F-MPPF is
a substrate of rodent P-glycoprotein (P-gp). However, in vitro assays suggest that MPPF is …
a substrate of rodent P-glycoprotein (P-gp). However, in vitro assays suggest that MPPF is …
[CITATION][C] Developing Targeted PET Tracers in the Era of Personalized Medicine
SMS Bohorquez, N van Bruggen… - Medicinal Chemistry …, 2013 - Wiley Online Library
This chapter contains sections titled: Imaging and Pharmacodynamics Biomarkers in Drug
Development General Considerations for Development of 11C‐and 18F‐labeled PET …
Development General Considerations for Development of 11C‐and 18F‐labeled PET …