Near-infrared luminescence high-contrast in vivo biomedical imaging

Y Chen, S Wang, F Zhang - Nature Reviews Bioengineering, 2023 - nature.com
Luminescence imaging in biomedical research has allowed new insights into the
architecture of pathological tissues, signalling networks and cell interactions, and is now …

Diverse applications of nanomedicine

B Pelaz, C Alexiou, RA Alvarez-Puebla, F Alves… - ACS …, 2017 - ACS Publications
The design and use of materials in the nanoscale size range for addressing medical and
health-related issues continues to receive increasing interest. Research in nanomedicine …

[HTML][HTML] Fluorescence-guided surgery

T Nagaya, YA Nakamura, PL Choyke… - Frontiers in …, 2017 - frontiersin.org
Surgical resection of cancer remains an important treatment modality. Despite advances in
preoperative imaging, surgery itself is primarily guided by the surgeon's ability to locate …

PET imaging with 89Zr: from radiochemistry to the clinic

MA Deri, BM Zeglis, LC Francesconi… - Nuclear medicine and …, 2013 - Elsevier
The advent of antibody-based cancer therapeutics has led to the concomitant rise in the
development of companion diagnostics for these therapies, particularly nuclear imaging …

[HTML][HTML] Intraoperative imaging-guided cancer surgery: from current fluorescence molecular imaging methods to future multi-modality imaging technology

C Chi, Y Du, J Ye, D Kou, J Qiu, J Wang, J Tian… - Theranostics, 2014 - ncbi.nlm.nih.gov
Cancer is a major threat to human health. Diagnosis and treatment using precision medicine
is expected to be an effective method for preventing the initiation and progression of cancer …

Near-infrared fluorescence imaging in immunotherapy

Y Ji, C Jones, Y Baek, GK Park, S Kashiwagi… - Advanced drug delivery …, 2020 - Elsevier
Near-infrared (NIR) light possesses many suitable optophysical properties for medical
imaging including low autofluorescence, deep tissue penetration, and minimal light …

Tumor-specific uptake of fluorescent bevacizumab–IRDye800CW microdosing in patients with primary breast cancer: a phase I feasibility study

LE Lamberts, M Koch, JS de Jong, ALL Adams… - Clinical Cancer …, 2017 - AACR
Purpose: To provide proof of principle of safety, breast tumor–specific uptake, and positive
tumor margin assessment of the systemically administered near-infrared fluorescent tracer …

Determination of tumor margins with surgical specimen mapping using near-infrared fluorescence

RW Gao, NT Teraphongphom, NS van den Berg… - Cancer research, 2018 - AACR
For many solid tumors, surgical resection remains the gold standard and tumor-involved
margins are associated with poor clinical outcomes. Near-infrared (NIR) fluorescence …

[HTML][HTML] Molecular and functional imaging in cancer-targeted therapy: current applications and future directions

JW Bai, SQ Qiu, GJ Zhang - Signal Transduction and Targeted Therapy, 2023 - nature.com
Targeted anticancer drugs block cancer cell growth by interfering with specific signaling
pathways vital to carcinogenesis and tumor growth rather than harming all rapidly dividing …

A mouse-human phase 1 co-clinical trial of a protease-activated fluorescent probe for imaging cancer

MJ Whitley, DM Cardona, AL Lazarides… - Science translational …, 2016 - science.org
Local recurrence is a common cause of treatment failure for patients with solid tumors.
Intraoperative detection of microscopic residual cancer in the tumor bed could be used to …