Imaging microglial activation with TSPO PET: lighting up neurologic diseases?
L Vivash, TJ O'Brien - Journal of Nuclear Medicine, 2016 - Soc Nuclear Med
Neuroinflammation is implicated in the pathogenesis of a wide range of neurologic and
neuropsychiatric diseases. For over 20 years, 11C-PK11195 PET, which aims to image …
neuropsychiatric diseases. For over 20 years, 11C-PK11195 PET, which aims to image …
Noninvasive molecular imaging of neuroinflammation
AH Jacobs, B Tavitian… - Journal of Cerebral …, 2012 - journals.sagepub.com
Inflammation is a highly dynamic and complex adaptive process to preserve and restore
tissue homeostasis. Originally viewed as an immune-privileged organ, the central nervous …
tissue homeostasis. Originally viewed as an immune-privileged organ, the central nervous …
TSPO PET for glioma imaging using the novel ligand 18F-GE-180: first results in patients with glioblastoma
NL Albert, M Unterrainer, DF Fleischmann… - European journal of …, 2017 - Springer
Objective The 18-kDa mitochondrial translocator protein (TSPO) was reported to be
upregulated in gliomas. 18 F-GE-180 is a novel 3rd generation TSPO receptor ligand with …
upregulated in gliomas. 18 F-GE-180 is a novel 3rd generation TSPO receptor ligand with …
The translocator protein
AM Scarf, M Kassiou - Journal of Nuclear Medicine, 2011 - Soc Nuclear Med
The translocator protein (TSPO) is expressed at low levels in the healthy human brain and is
markedly upregulated in response to brain injury and inflammation. This increase in TSPO …
markedly upregulated in response to brain injury and inflammation. This increase in TSPO …
[HTML][HTML] A perspective on the radiopharmaceutical requirements for imaging and therapy of glioblastoma
J Bolcaen, J Kleynhans, S Nair, J Verhoeven… - Theranostics, 2021 - ncbi.nlm.nih.gov
Despite numerous clinical trials and pre-clinical developments, the treatment of glioblastoma
(GB) remains a challenge. The current survival rate of GB averages one year, even with an …
(GB) remains a challenge. The current survival rate of GB averages one year, even with an …
Quantitative in vivo cell-surface receptor imaging in oncology: kinetic modeling and paired-agent principles from nuclear medicine and optical imaging
The development of methods to accurately quantify cell-surface receptors in living tissues
would have a seminal impact in oncology. For example, accurate measures of receptor …
would have a seminal impact in oncology. For example, accurate measures of receptor …
Imaging of the glioma microenvironment by TSPO PET
Gliomas are highly dynamic and heterogeneous tumours of the central nervous system
(CNS). They constitute the most common neoplasm of the CNS and the second most …
(CNS). They constitute the most common neoplasm of the CNS and the second most …
Translocator protein 18 kDa negatively regulates inflammation in microglia
KR Bae, HJ Shim, D Balu, SR Kim, SW Yu - Journal of neuroimmune …, 2014 - Springer
Translocator protein 18 kDa (TSPO) is a mitochondrial outer membrane protein. Although
TSPO expression is up-regulated during neuroinflammation, the role of TSPO and its …
TSPO expression is up-regulated during neuroinflammation, the role of TSPO and its …
Combined PET imaging of the inflammatory tumor microenvironment identifies margins of unique radiotracer uptake
B Zinnhardt, H Pigeon, B Thézé, T Viel, L Wachsmuth… - Cancer research, 2017 - AACR
The tumor microenvironment is highly heterogeneous. For gliomas, the tumor-associated
inflammatory response is pivotal to support growth and invasion. Factors of glioma growth …
inflammatory response is pivotal to support growth and invasion. Factors of glioma growth …
The 18-kDa mitochondrial translocator protein in human gliomas: an 11C-(R) PK11195 PET imaging and neuropathology study
Z Su, F Roncaroli, PF Durrenberger… - Journal of Nuclear …, 2015 - Soc Nuclear Med
The 18-kDa mitochondrial translocator protein (TSPO) is upregulated in high-grade
astrocytomas and can be imaged by PET using the selective radiotracer 11C-(R) PK11195 …
astrocytomas and can be imaged by PET using the selective radiotracer 11C-(R) PK11195 …