Optimal cardiac function depends on proper timing of excitation and contraction in various
regions of the heart, as well as on appropriate heart rate. This is accomplished via …

Sympathetic activity plays an important role in modulation of cardiac rhythm. Indeed, while
exerting positive tropic effects in response to physiologic and pathologic stressors, β …

Objectives: The study objectives were to create a cardiac metaiodobenzylguanidine (m IBG)
database using multiple prospective cohort studies and to determine the quantitative iodine …

The nervous system and cardiovascular system develop in concert and are functionally
interconnected in both health and disease. This white paper focuses on the cellular and …

Abnormalities in the cardiac sympathetic nervous system have been documented in various
heart diseases and have been directly implicated in their pathogenesis and disease …

Sympathetic neurons densely innervate the myocardium with non‐random topology and
establish structured contacts (ie neuro‐cardiac junctions, NCJ) with cardiomyocytes …

Millions of people suffer a myocardial infarction (MI) every year, and those who survive have
increased risk of arrhythmias and sudden cardiac death. Recent clinical studies have …

Cardiac function is under the control of the autonomic nervous system, composed by the
parasympathetic and sympathetic divisions, which are finely tuned at different hierarchical …

2 Gardner et al Sympathetic Remodeling and Arrhythmias excitability of postganglionic
neurons may also contribute to elevated adrenergic transmission in the heart. Neuronal cell …

Cardiac neuroimaging with 123 I-metaiodobenzylguanidine (123 I-MIBG) has been officially
used in clinical practice in Japan since 1992. The nuclear cardiology guidelines of the …