Immuno-positron emission tomography (immunoPET) is a paradigm-shifting molecular
imaging modality combining the superior targeting specificity of monoclonal antibody (mAb) …

Affibody molecules are a class of engineered affinity proteins with proven potential for
therapeutic, diagnostic and biotechnological applications. Affibody molecules are small (6.5 …

Highlights•Non-antibody scaffold drugs are a promising new class of biologics drugs.•The
first candidate scaffolds are now moving into clinical development and practice.•Challenges …

Affibody molecules can be used as tools for molecular recognition in diagnostic and
therapeutic applications. There are several preclinical studies reported on diagnostic and …

Purpose: Positron Emission Tomography (PET) imaging of HER2 expression could
potentially be used to select patients for HER2-targed therapy, predict response based on …

The concept of engineering robust protein scaffolds for novel binding functions emerged 20
years ago, one decade after the advent of recombinant antibody technology. Early examples …

The expression status of human epidermal growth factor receptor type 2 (HER2) predicts the
response of HER2-targeted therapy in breast cancer. ABY-025 is a small reengineered …

Accurate determination of tumor human epidermal growth factor receptor 2 (HER2)‐status in
breast cancer patients is possible via noninvasive imaging, provided adequate tracers are …

Affibody molecules are small (58 amino acids) engineered scaffold proteins that can be
selected to bind to a large variety of proteins with a high affinity. Their small size and high …

Introduction: Over the past decade, several library-based methods have been developed to
discover ligands with strong binding affinities for their targets. These methods mimic the …