Paclitaxel is a widely used anti-tumor chemotherapeutic drug. Solvent-based paclitaxel
causes bone marrow suppression, allergic reactions, neurotoxicity and systemic toxicity …

Purpose: Brain metastases of breast cancer appear to be increasing in incidence, confer
significant morbidity, and threaten to compromise gains made in systemic chemotherapy …

One major characteristic of programmed cell death (apoptosis) results in the increased
expression of phosphatidylserine (PS) on the outer membrane of dying cells. Consequently …

Successful treatment of cancer patients requires balancing of the dose, timing, and type of
therapeutic regimen. Detection of increased cell death may serve as a predictor of the …

Many antineoplastic agents induce myelosuppression and leukopenia as secondary effects
in patients. The development of anticancer agents that simultaneously provoke antitumor …

Abstract Purpose 99m Tc-Annexin A5 has been used as a molecular imaging probe for the
visualization, characterization and measurement of apoptosis. In an effort to define the …

Photodynamic therapy (PDT) is an established therapeutic modality that uses nonionizing
near‐infrared light to activate photocytotoxicity of endogenous or exogenous …

Chemotherapy is more effective in the treatment of peripheral tumors than brain metastases,
likely reflecting the reduced ability of chemotherapy to cross the blood-brain barrier (BBB) …

Objectives: Most chemotherapy agents cause tumor cell death primarily by the induction of
apoptosis. The ability to noninvasively image apoptosis in vivo could dramatically benefit pre …

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) exhibits cancer-selective
killing activity representing a promising anticancer therapeutic strategy. Adenovirus Delta-24 …