[HTML][HTML] Auger electrons for cancer therapy–a review
Abstract Background Auger electrons (AEs) are very low energy electrons that are emitted
by radionuclides that decay by electron capture (eg 111 In, 67 Ga, 99m Tc, 195m Pt, 125 I …
by radionuclides that decay by electron capture (eg 111 In, 67 Ga, 99m Tc, 195m Pt, 125 I …
Radioimmunotherapy of cancer with high linear energy transfer (LET) radiation delivered by radionuclides emitting α-particles or Auger electrons
Radioimmunotherapy (RIT) aims to selectively deliver radionuclides emitting α-particles, β-
particles or Auger electrons to tumors by conjugation to monoclonal antibodies (mAbs) that …
particles or Auger electrons to tumors by conjugation to monoclonal antibodies (mAbs) that …
Molecularly targeted gold nanoparticles enhance the radiation response of breast cancer cells and tumor xenografts to X-radiation
N Chattopadhyay, Z Cai, YL Kwon, E Lechtman… - Breast cancer research …, 2013 - Springer
The purpose of this study was to evaluate the effect of molecularly targeted gold
nanoparticles (AuNPs) on tumor radiosensitization both in vitro and in vivo. Human …
nanoparticles (AuNPs) on tumor radiosensitization both in vitro and in vivo. Human …
A Monte Carlo-based model of gold nanoparticle radiosensitization accounting for increased radiobiological effectiveness
E Lechtman, S Mashouf… - Physics in Medicine …, 2013 - iopscience.iop.org
Radiosensitization using gold nanoparticles (AuNPs) has been shown to vary widely with
cell line, irradiation energy, AuNP size, concentration and intracellular localization. We …
cell line, irradiation energy, AuNP size, concentration and intracellular localization. We …
Targeting the nucleus: an overview of Auger-electron radionuclide therapy
B Cornelissen, KA Vallis - Current drug discovery technologies, 2010 - ingentaconnect.com
The review presented here lays out the present state of the art in the field of radionuclide
therapies specifically targeted against the nucleus of cancer cells, focussing on the use of …
therapies specifically targeted against the nucleus of cancer cells, focussing on the use of …
Radiation Nanomedicine for EGFR-Positive Breast Cancer: Panitumumab-Modified Gold Nanoparticles Complexed to the β-Particle-Emitter, 177Lu
Our objective was to construct a novel radiation nanomedicine for treatment of breast cancer
(BC) expressing epidermal growth factor receptors (EGFR), particularly triple-negative …
(BC) expressing epidermal growth factor receptors (EGFR), particularly triple-negative …
Calculation of cellular S-values using Geant4-DNA: The effect of cell geometry
Purpose Geant4-DNA is used to calculate S-values for different subcellular distributions of
low-energy electron sources in various cell geometries. Method Calculations of cellular S …
low-energy electron sources in various cell geometries. Method Calculations of cellular S …
Panitumumab-DOTA-111In: An Epidermal Growth Factor Receptor Targeted Theranostic for SPECT/CT Imaging and Meitner–Auger Electron Radioimmunotherapy of …
Epidermal growth factor receptors (EGFR) are overexpressed in triple-negative breast
cancer (TNBC) and are an attractive target for the development of theranostic …
cancer (TNBC) and are an attractive target for the development of theranostic …
[HTML][HTML] Interplay between the gold nanoparticle sub-cellular localization, size, and the photon energy for radiosensitization
E Lechtman, JP Pignol - Scientific reports, 2017 - nature.com
There are large variations in the reported efficiency of gold nanoparticle (GNP)
radiosensitization. We have previously reported on a predictive model, which accounts for …
radiosensitization. We have previously reported on a predictive model, which accounts for …
Monte Carlo N-particle (MCNP) modeling of the cellular dosimetry of 64Cu: comparison with MIRDcell S values and implications for studies of its cytotoxic effects
64Cu emits positrons as well as β− particles and Auger and internal conversion electrons
useful for radiotherapy. Our objective was to model the cellular dosimetry of 64Cu under …
useful for radiotherapy. Our objective was to model the cellular dosimetry of 64Cu under …