The intricate role of CXCR4 in cancer
Chemokines mediate numerous physiological and pathological processes related primarily
to cell homing and migration. The chemokine CXCL12, also known as stromal cell-derived …
to cell homing and migration. The chemokine CXCL12, also known as stromal cell-derived …
[HTML][HTML] CXCR4-directed theranostics in oncology and inflammation
Given its prominent role in inflammation and cancer biology, the CXC motif chemokine
receptor 4 (CXCR4) has gained a lot of attention in the recent years. This review gives a …
receptor 4 (CXCR4) has gained a lot of attention in the recent years. This review gives a …
CXCR4 ligands: the next big hit?
AME Walenkamp, C Lapa, K Herrmann… - Journal of Nuclear …, 2017 - Soc Nuclear Med
The G protein–coupled protein receptor CXC chemokine receptor 4 (CXCR4) is an attractive
target for cancer diagnosis and treatment, as it is overexpressed in many solid and …
target for cancer diagnosis and treatment, as it is overexpressed in many solid and …
[HTML][HTML] Insight into the Development of PET Radiopharmaceuticals for Oncology
While the development of positron emission tomography (PET) radiopharmaceuticals
closely follows that of traditional drug development, there are several key considerations in …
closely follows that of traditional drug development, there are several key considerations in …
[HTML][HTML] Disclosing the CXCR4 expression in lymphoproliferative diseases by targeted molecular imaging
Chemokine ligand-receptor interactions play a pivotal role in cell attraction and cellular
trafficking, both in normal tissue homeostasis and in disease. In cancer, chemokine receptor …
trafficking, both in normal tissue homeostasis and in disease. In cancer, chemokine receptor …
PET of CXCR4 expression by a 68Ga-labeled highly specific targeted contrast agent
E Gourni, O Demmer, M Schottelius… - Journal of Nuclear …, 2011 - Soc Nuclear Med
The overexpression of the chemokine receptor CXCR4 plays an important role in oncology,
since together with its endogenous ligand, the stromal cell–derived factor (SDF1-α), CXCR4 …
since together with its endogenous ligand, the stromal cell–derived factor (SDF1-α), CXCR4 …
The CXCR4 inhibitor BL-8040 induces the apoptosis of AML blasts by downregulating ERK, BCL-2, MCL-1 and cyclin-D1 via altered miR-15a/16-1 expression
M Abraham, S Klein, B Bulvik, H Wald, ID Weiss… - Leukemia, 2017 - nature.com
CXCR4 is a key player in the retention and survival of human acute myeloid leukemia (AML)
blasts in the bone marrow (BM) microenvironment. We studied the effects of the CXCR4 …
blasts in the bone marrow (BM) microenvironment. We studied the effects of the CXCR4 …
Development of individualized anti-metastasis strategies by engineering nanomedicines
Q He, S Guo, Z Qian, X Chen - Chemical Society Reviews, 2015 - pubs.rsc.org
Metastasis is deadly and also tough to treat as it is much more complicated than the primary
tumour. Anti-metastasis approaches available so far are far from being optimal. A variety of …
tumour. Anti-metastasis approaches available so far are far from being optimal. A variety of …
At the Bench: Pre-clinical evidence for multiple functions of CXCR4 in cancer
Signaling through chemokine receptor, CXC chemokine receptor type 4 (CXCR4) regulates
essential processes in normal physiology, including embryogenesis, tissue repair …
essential processes in normal physiology, including embryogenesis, tissue repair …
[HTML][HTML] A Comprehensive Review of Non-Covalent Radiofluorination Approaches Using Aluminum [18F]fluoride: Will [18F]AlF Replace 68Ga for Metal Chelate …
C Fersing, A Bouhlel, C Cantelli, P Garrigue… - Molecules, 2019 - mdpi.com
Due to its ideal physical properties, fluorine-18 turns out to be a key radionuclide for positron
emission tomography (PET) imaging, for both preclinical and clinical applications. However …
emission tomography (PET) imaging, for both preclinical and clinical applications. However …