Immuno-positron emission tomography (immunoPET) is a paradigm-shifting molecular
imaging modality combining the superior targeting specificity of monoclonal antibody (mAb) …

Immunotherapy, specifically the introduction of immune checkpoint inhibitors, has
transformed the treatment of cancer, enabling long-term tumour control even in individuals …

Noninvasive molecular imaging approaches include nuclear, optical, magnetic resonance
imaging, computed tomography, ultrasound, and photoacoustic imaging, which require …

The noninvasive detection and quantification of CD8+ T cells in vivo are important for both
the detection and staging of CD8+ lymphomas and for the monitoring of successful cancer …

Antibodies have long been recognised as potent vectors for carrying diagnostic medical
radionuclides, contrast agents and optical probes to diseased tissue for imaging. The area of …

Identification of cancer cell–surface biomarkers and advances in antibody engineering have
led to a sharp increase in the development of therapeutic antibodies. These same advances …

We conducted a phase I dose-escalation study with 89Zr-desferrioxamine-IAB2M (89Zr-
IAB2M), an anti–prostate-specific membrane antigen minibody, in patients with metastatic …

Antibody technology has transformed drug development, providing robust approaches to
producing highly targeted and active therapeutics that can routinely be advanced through …

Highlights•36 out of 39 approved therapeutic antibodies are native full-length IgG.•Antibody
engineering may increase potency and improve safety of native antibodies.•Next generation …

The recent clinical success of cancer immunotherapy has renewed interest in the
development of tools to image the immune system. In general, immunotherapies attempt to …