Adrenomedullin in cardiovascular disease: a useful biomarker, its pathological roles and therapeutic application
T Nishikimi, K Kuwahara, Y Nakagawa… - Current Protein and …, 2013 - ingentaconnect.com
Many neurohumoral factors play important roles in the regulation of the cardiovascular
system and in the pathophysiology of cardiovascular disease. Adrenomedullin (AM) is a …
system and in the pathophysiology of cardiovascular disease. Adrenomedullin (AM) is a …
Al [18F] F-complexation of DFH17, a NOTA-conjugated adrenomedullin analog, for PET imaging of pulmonary circulation
LMA Martinez, F Harel, QT Nguyen… - Nuclear medicine and …, 2018 - Elsevier
Introduction Adrenomedullin receptors are highly expressed in human alveolar capillaries
and provide a molecular target for imaging the integrity of pulmonary microcirculation. In this …
and provide a molecular target for imaging the integrity of pulmonary microcirculation. In this …
[HTML][HTML] PulmoBind imaging measures reduction of vascular adrenomedullin receptor activity with lack of effect of sildenafil in pulmonary hypertension
N Merabet, MJ Nsaibia, QT Nguyen, YF Shi… - Scientific Reports, 2019 - nature.com
Endothelial dysfunction is a core pathophysiologic process in pulmonary arterial
hypertension (PAH). We developed PulmoBind (PB), a novel imaging biomarker of the …
hypertension (PAH). We developed PulmoBind (PB), a novel imaging biomarker of the …
[HTML][HTML] Molecular imaging of the human pulmonary vascular endothelium in pulmonary hypertension: a phase II safety and proof of principle trial
F Harel, D Langleben, S Provencher, A Fournier… - European journal of …, 2017 - Springer
Purpose The adrenomedullin receptor is densely expressed in the pulmonary vascular
endothelium. PulmoBind, an adrenomedullin receptor ligand, was developed for molecular …
endothelium. PulmoBind, an adrenomedullin receptor ligand, was developed for molecular …
Molecular imaging of the human pulmonary vascular endothelium using an adrenomedullin receptor ligand
F Harel, X Levac, QT Nguyen… - Molecular …, 2015 - journals.sagepub.com
This phase I study (NCT01539889) evaluated the safety, efficacy, and dosing of PulmoBind
for molecular imaging of pulmonary circulation. PulmoBind is a ligand of the adrenomedullin …
for molecular imaging of pulmonary circulation. PulmoBind is a ligand of the adrenomedullin …
PulmoBind, an adrenomedullin-based molecular lung imaging tool
M Létourneau, QT Nguyen, F Harel… - Journal of Nuclear …, 2013 - Soc Nuclear Med
Previous studies showed that adrenomedullin (AM) could be a promising agent for
molecular imaging of the pulmonary circulation, with abundant specific binding sites at the …
molecular imaging of the pulmonary circulation, with abundant specific binding sites at the …
[HTML][HTML] Molecular imaging of the pulmonary circulation in health and disease
The pulmonary circulation, at the unique crossroads between the left and the right heart, is
submitted to large physiologic hemodynamic variations and possesses numerous important …
submitted to large physiologic hemodynamic variations and possesses numerous important …
[HTML][HTML] SPECT and PET imaging of adrenomedullin receptors: a promising strategy for studying pulmonary vascular diseases
LMA Martinez, F Harel, M Létourneau… - American journal of …, 2019 - ncbi.nlm.nih.gov
Circulating adrenomedullin (AM) levels are elevated in several cardiovascular diseases,
including pulmonary vascular diseases causing pulmonary hypertension. To date the …
including pulmonary vascular diseases causing pulmonary hypertension. To date the …
[HTML][HTML] Evaluation of pulmonary perfusion by SPECT imaging using an endothelial cell tracer in supine humans and dogs
X Levac, F Harel, V Finnerty, QT Nguyen… - EJNMMI research, 2016 - Springer
Background Pulmonary perfusion is not spatially homogeneously distributed, and its
variations could be of diagnostic value in lung vascular disease. PulmoBind is a ligand of …
variations could be of diagnostic value in lung vascular disease. PulmoBind is a ligand of …
Characterization of iodinated adrenomedullin derivatives suitable for lung nuclear medicine
Y Fu, M Létourneau, D Chatenet, J Dupuis… - Nuclear medicine and …, 2011 - Elsevier
INTRODUCTION: We have recently demonstrated the effectiveness of 99m-technetium
adrenomedullin (AM) as a new molecular lung imaging agent that could provide significant …
adrenomedullin (AM) as a new molecular lung imaging agent that could provide significant …