The principles and applications of avidin-based nanoparticles in drug delivery and diagnosis

A Jain, K Cheng - Journal of controlled release, 2017 - Elsevier
Avidin-biotin interaction is one of the strongest non-covalent interactions in the nature.
Avidin and its analogues have therefore been extensively utilized as probes and affinity …

[HTML][HTML] An update on in vivo imaging of extracellular vesicles as drug delivery vehicles

P Gangadaran, CM Hong, BC Ahn - Frontiers in pharmacology, 2018 - frontiersin.org
Extracellular vesicles (EVs) are currently being considered as promising drug delivery
vehicles. EVs are naturally occurring vesicles that exhibit many characteristics favorable to …

Quantitative analysis of tissue distribution of the B16BL6-derived exosomes using a streptavidin-lactadherin fusion protein and iodine-125-labeled biotin derivative …

M Morishita, Y Takahashi, M Nishikawa, K Sano… - Journal of …, 2015 - Elsevier
We previously succeeded in the visualization of tissue distribution of B16BL6 cells-derived
exosomes by labeling with Gaussia luciferase (gLuc)-LA, a fusion protein of gLuc (a reporter …

[HTML][HTML] The role of imaging biomarkers to guide pharmacological interventions targeting tumor hypoxia

B Gallez - Frontiers in pharmacology, 2022 - frontiersin.org
Hypoxia is a common feature of solid tumors that contributes to angiogenesis, invasiveness,
metastasis, altered metabolism and genomic instability. As hypoxia is a major actor in tumor …

[HTML][HTML] Radionuclide imaging and therapy directed towards the tumor microenvironment: A multi-cancer approach for personalized medicine

CD van der Heide, SU Dalm - European Journal of Nuclear Medicine and …, 2022 - Springer
Targeted radionuclide theranostics is becoming more and more prominent in clinical
oncology. Currently, most nuclear medicine compounds researched for cancer theranostics …

Hypoxia-driven immunosuppression: a new reason to use thermal therapy in the treatment of cancer?

CT Lee, T Mace, EA Repasky - International Journal of …, 2010 - Taylor & Francis
Hypoxia within the tumour microenvironment is correlated with poor treatment outcome after
radiation and chemotherapy, and with decreased overall survival in cancer patients. Several …

18F-fluoromisonidazole PET uptake is correlated with hypoxia-inducible factor-1α expression in oral squamous cell carcinoma

J Sato, Y Kitagawa, Y Yamazaki, H Hata… - Journal of Nuclear …, 2013 - Soc Nuclear Med
Hypoxia is a common feature of cancer and a prognostic factor for many types of cancer. 18F-
fluoromisonidazole (18F-FMISO) PET can detect tumor hypoxia noninvasively. Hypoxia …

In vivo molecular imaging

H Saji - Biological and Pharmaceutical Bulletin, 2017 - jstage.jst.go.jp
In vivo molecular imaging is the visualization, characterization, and measurement of
biological processes at the molecular and cellular levels in humans and other living …

Oroxylin A regulates glucose metabolism in response to hypoxic stress with the involvement of Hypoxia‐inducible factor‐1 in human hepatoma HepG2 cells

Q Dai, Q Yin, L Wei, Y Zhou, C Qiao… - Molecular …, 2016 - Wiley Online Library
Metabolic alteration in cancer cells is one of the most conspicuous characteristics that
distinguish cancer cells from normal cells. In this study, we investigated the influence and …

Imaging the Hypoxic Tumor Microenvironment in Cancer Models

A Parihar, P Sharma, M Sharma, R Khan - Hypoxia in Cancer: Significance …, 2023 - Springer
In hypoxic condition oxygen supply is disrupted, and it happens in myocardial infarction,
stroke, or tumorous growth. If cells in normal tissue lose their oxygen supply abruptly, they …