Cardiac PET perfusion tracers: current status and future directions
J Maddahi, RRS Packard - Seminars in nuclear medicine, 2014 - Elsevier
PET myocardial perfusion imaging (MPI) is increasingly being used for noninvasive
detection and evaluation of coronary artery disease. However, the widespread use of PET …
detection and evaluation of coronary artery disease. However, the widespread use of PET …
[HTML][HTML] Molecular imaging of apoptosis: from micro to macro
Apoptosis, or programmed cell death, is involved in numerous human conditions including
neurodegenerative diseases, ischemic damage, autoimmune disorders and many types of …
neurodegenerative diseases, ischemic damage, autoimmune disorders and many types of …
In vivo imaging of mitochondrial membrane potential in non-small-cell lung cancer
M Momcilovic, A Jones, ST Bailey, CM Waldmann, R Li… - Nature, 2019 - nature.com
Mitochondria are essential regulators of cellular energy and metabolism, and have a crucial
role in sustaining the growth and survival of cancer cells. A central function of mitochondria …
role in sustaining the growth and survival of cancer cells. A central function of mitochondria …
Preclinical imaging: an essential ally in modern biosciences
L Cunha, I Horvath, S Ferreira, J Lemos… - Molecular diagnosis & …, 2014 - Springer
Translational research is changing the practice of modern medicine and the way in which
health problems are approached and solved. The use of small-animal models in basic and …
health problems are approached and solved. The use of small-animal models in basic and …
Biomarkers and molecular probes for cell death imaging and targeted therapeutics
BA Smith, BD Smith - Bioconjugate chemistry, 2012 - ACS Publications
Cell death is a critically important biological process. Disruption of homeostasis, either by
excessive or deficient cell death, is a hallmark of many pathological conditions. Recent …
excessive or deficient cell death, is a hallmark of many pathological conditions. Recent …
Small-animal PET: what is it, and why do we need it?
Small-animal PET refers to imaging of animals such as rats and mice using dedicated PET
scanners. Small-animal PET has been used extensively in modern biomedical research. It …
scanners. Small-animal PET has been used extensively in modern biomedical research. It …
Apoptosis imaging: beyond annexin V
Induction of apoptosis is the primary mechanism through which most chemotherapies cause
tumor cell death. Early assessment of tumor response is required to manage patients in …
tumor cell death. Early assessment of tumor response is required to manage patients in …
Imaging cell death
AA Neves, KM Brindle - Journal of Nuclear Medicine, 2014 - Soc Nuclear Med
There is currently a need for imaging methods capable of detecting cell death in tissues and
the early onset of tumor cell death resulting from therapy. However, to date, no probe has …
the early onset of tumor cell death resulting from therapy. However, to date, no probe has …
18F-ML-10, a PET tracer for apoptosis: first human study
J Höglund, A Shirvan, G Antoni… - Journal of Nuclear …, 2011 - Soc Nuclear Med
Clinical PET of apoptosis may have substantial value in advancing patient care. We report
here the first-in-humans study with 18F-labeled 2-(5-fluoropentyl)-2-methyl malonic acid …
here the first-in-humans study with 18F-labeled 2-(5-fluoropentyl)-2-methyl malonic acid …
Absolute quantitation of myocardial blood flow in human subjects with or without myocardial ischemia using dynamic flurpiridaz F 18 PET
RRS Packard, SC Huang, M Dahlbom… - Journal of Nuclear …, 2014 - Soc Nuclear Med
Absolute quantitation of myocardial blood flow (MBF) by PET is an established method of
analyzing coronary artery disease (CAD) but subject to the various shortcomings of …
analyzing coronary artery disease (CAD) but subject to the various shortcomings of …