Use of selective in-vivo tau imaging will enable improved understanding of tau aggregation
in the brain, facilitating research into causes, diagnosis, and treatment of major tauopathies …

The Alzheimer center of the VU University Medical Center opened in 2000 and was initiated
to combine both patient care and research. Together, to date, all patients forming the …

Objective The most widely studied positron emission tomography ligand for in vivo β‐
amyloid imaging is 11C‐Pittsburgh compound B (11C‐PIB). Its availability, however, is …

Since its opening in 2000, patient care and research go hand in hand at the Alzheimer
center of the VU University Medical Center, both organized in such a way that they mutually …

In Alzheimer disease (AD), which is the most common cause of dementia, the underlying
disease pathology most probably precedes the onset of cognitive symptoms by many years …

β-amyloid plaques (Aβ plaques) in the brain, containing predominantly fibrillary Aβ peptide
aggregates, represent a defining pathologic feature of Alzheimer disease (AD). Imaging …

Background/aims As a protrusion from the brain, the retina might reflect the status of the
brain. Previous studies showed a decrease in vessel density and foveal avascular zone …

Neurofibrillary tangles in Alzheimer disease (AD) brains are composed of the microtubule-
associated protein tau. Noninvasive monitoring of tau protein aggregates in the living brain …

A major pathological hallmark of Alzheimer's disease is accumulation of amyloid-β in senile
plaques in the brain. Evidence is accumulating that decreased clearance of amyloid-β from …

Brain microbleeds are small dot-like lesions appearing as hyposignals on gradient echo
magnetic resonance sequences. In Alzheimer's disease, brain microbleeds are of special …