Every year, an estimated 1.7 million Americans sustain brain injury. Long-term disabilities
impact nearly half of moderate brain injury survivors and nearly 50,000 of these cases result …

Traumatic brain injury (TBI) remains one of the most prevalent forms of morbidity among
Veterans and Service Members, particularly for those engaged in the conflicts in Iraq and …

Purpose Neuroinflammation plays a critical role in various neuropathological conditions,
and hence there is renewed interest in the translocator protein (TSPO) as a biomarker of …

Purpose The novel PET tracer [11 C] SMW139 binds with high affinity to the P2X 7 receptor,
which is expressed on pro-inflammatory microglia. The purposes of this first in-man study …

Background Over the past decades, positron emission tomography (PET) imaging has
become an increasingly useful research modality in the field of multiple sclerosis (MS) …

Purpose Over the past 20 years, neuroinflammation (NI) has increasingly been recognised
as having an important role in many neurodegenerative diseases, including Alzheimer's …

Traumatic brain injury (TBI) initiates molecular and cellular pathologies that underlie post-
injury morbidities, including hippocampus-related memory decline and epileptogenesis …

The application of positron emission tomography (PET) in brain research has increased
substantially during the past 20 years, and is still growing. PET provides a unique insight …

Experimental and clinical evidence suggests that neuroinflammation, triggered by
epileptogenic insults, contributes to seizure development. We used translocator protein …

Our objective was to measure (R)-11C-PK11195 binding as an indirect marker of neuronal
damage after traumatic brain injury (TBI). Methods: Dynamic (R)-11C-PK11195 PET scans …