18F-Labeling of Arenes and Heteroarenes for Applications in Positron Emission Tomography

S Preshlock, M Tredwell, V Gouverneur - Chemical reviews, 2016 - ACS Publications
Diverse radiochemistry is an essential component of nuclear medicine; this includes
imaging techniques such as positron emission tomography (PET). As such, PET can track …

Chemistry for Positron Emission Tomography: Recent Advances in 11C‐, 18F‐, 13N‐, and 15O‐Labeling Reactions

X Deng, J Rong, L Wang, N Vasdev… - Angewandte Chemie …, 2019 - Wiley Online Library
Positron emission tomography (PET) is a molecular imaging technology that provides
quantitative information about function and metabolism in biological processes in vivo for …

A General Copper‐Mediated Nucleophilic 18F Fluorination of Arenes

M Tredwell, SM Preshlock, NJ Taylor… - Angewandte Chemie …, 2014 - Wiley Online Library
Molecules labeled with fluorine‐18 are used as radiotracers for positron emission
tomography. An important challenge is the labeling of arenes not amenable to aromatic …

Copper-Catalyzed [18F]Fluorination of (Mesityl)(aryl)iodonium Salts

N Ichiishi, AF Brooks, JJ Topczewski, ME Rodnick… - Organic …, 2014 - ACS Publications
A practical, rapid, and highly regioselective Cu-catalyzed radiofluorination of (mesityl)(aryl)
iodonium salts is described. This protocol utilizes [18F] KF to access 18F-labeled electron …

[HTML][HTML] Spirocyclic hypervalent iodine (III)-mediated radiofluorination of non-activated and hindered aromatics

BH Rotstein, NA Stephenson, N Vasdev… - Nature …, 2014 - nature.com
Abstract Fluorine-18 (t ½= 109.7 min) is the most commonly used isotope to prepare
radiopharmaceuticals for molecular imaging by positron emission tomography (PET) …

Radiosynthesis and Evaluation of [18F]Selectfluor bis(triflate)

H Teare, EG Robins, A Kirjavainen… - Angewandte Chemie …, 2010 - Wiley Online Library
Positron (β+) emission tomography (PET) is a noninvasive molecular imaging technique that
allows for the invivo investigation of physiological processes.[1] As a radioisotope, fluorine …

Arene radiofluorination enabled by photoredox-mediated halide interconversion

W Chen, H Wang, NES Tay, VA Pistritto, KP Li… - Nature …, 2022 - nature.com
Positron emission tomography (PET) is a powerful imaging technology that can visualize
and measure metabolic processes in vivo and/or obtain unique information about drug …

One-pot synthesis of high molar activity 6-[18 F] fluoro-l-DOPA by Cu-mediated fluorination of a BPin precursor

AV Mossine, SS Tanzey, AF Brooks… - Organic & …, 2019 - pubs.rsc.org
A one-pot two-step synthesis of 6-[18F] fluoro-L-DOPA ([18F] FDOPA) has been developed
involving Cu-mediated radiofluorination of a pinacol boronate ester precursor. The method …

Synthesis of high-molar-activity [18F]6-fluoro-l-DOPA suitable for human use via Cu-mediated fluorination of a BPin precursor

AV Mossine, SS Tanzey, AF Brooks, KJ Makaravage… - Nature protocols, 2020 - nature.com
Abstract [18F] 6-fluoro-l-DOPA ([18F] FDOPA) is a diagnostic radiopharmaceutical for
positron emission tomography (PET) imaging that is used to image Parkinson's disease …

Isotope Exchange-Based 18F-Labeling Methods

T Wang, S Lv, Z Mou, Z Zhang, T Dong… - Bioconjugate …, 2023 - ACS Publications
18F-Labeling methods for the preparation of 18F-labeled molecular probes can be classified
into electrophilic fluorination, nucleophilic fluorination, metal-F coordination, and 18F/19F …