The glucagon-like peptide (GLP)-1 receptor (GLP-1R) is a class BG protein–coupled
receptor (GPCR) that mediates the action of GLP-1, a peptide hormone secreted from three …

Glucagon-like peptide-1 (GLP-1) is an incretin that plays important physiological roles in
glucose homeostasis. Produced from intestine upon food intake, it stimulates insulin …

Vesicular monoamine transporters (VMAT) are responsible for the uptake of cytosolic
monoamines into synaptic vesicles in monoaminergic neurons. Two closely related VMATs …

Positron emission tomography (PET)/computed tomography (CT) is a rapidly expanding
imaging modality, thanks to the availability of compact medical cyclotrons and automated …

The ability to noninvasively measure endogenous pancreatic β-cell mass (BCM) would
accelerate research on the pathophysiology of diabetes and revolutionize the preclinical …

Radiotracer imaging is characterised by high in vivo sensitivity, with a detection limit in the
lower picomolar range. Therefore, radiotracers represent a valuable tool for imaging …

Since diabetes is becoming a global epidemic, there is a great need to develop early β-cell
specific diagnostic techniques for this disorder. There are two types of diabetes (ie, type 1 …

Type 2 vesicular monoamine transporter (VMAT2), found in the brain, is also expressed by β-
cells of the pancreas in association with insulin. Preclinical experiments suggested that 11C …

Glucagon-like peptide 1 receptor (GLP-1R) is highly expressed in pancreatic islets,
especially on β-cells. Therefore, a properly labeled ligand that binds to GLP-1R could be …

The noninvasive measurement of functional β-cell mass would be clinically valuable for
monitoring the progression of type 1 and type 2 diabetes as well as the viability of …