Developing new molecular imaging probes for PET

K Serdons, A Verbruggen, GM Bormans - Methods, 2009 - Elsevier
Positron emission tomography (PET) is a fully translational molecular imaging technique that
requires specific probes radiolabelled with short-lived positron emitting radionuclides. This …

A wireless beta-microprobe based on pixelated silicon for in vivo brain studies in freely moving rats

J Maerk, D Benoit, L Balasse, M Benoit… - Physics in Medicine …, 2013 - iopscience.iop.org
The investigation of neurophysiological mechanisms underlying the functional specificity of
brain regions requires the development of technologies that are well adjusted to in vivo …

PIXSIC, a Pixelated β+-Sensitive Probe for Radiopharmacological Investigations in Rat Brain: Binding Studies with [18F]MPPF

L Balasse, J Maerk, F Pain, A Genoux, S Fieux… - Molecular Imaging and …, 2015 - Springer
Purpose The aim of this work was to demonstrate the pharmacokinetic potential of a wireless
pixelated β+-sensitive probe (PIXSIC). Procedures The binding of 2′-methoxyphenyl-(N …

PIXSIC: a pixellated beta-microprobe for kinetic measurements of radiotracers on awake and freely moving small animals

J Godart, P Weiss, B Chantepie… - … on Nuclear Science, 2010 - ieeexplore.ieee.org
We present a design study of PIXSIC, a new β+ radiosensitive microprobe implantable in
rodent brain dedicated to in vivo and autonomous measurements of local time activity curves …

Synthesis and characterisation of a radioligand for positron emission tomography imaging of the 5-HT 1A receptor

C McCardle - 2015 - theses.ncl.ac.uk
Dysfunction of the central 5-HT system has been implicated in affective disorders such as
anxiety and depression. However, one factor which has restricted the progress of …

Compartmental investigation of brain energy metabolism using radiotracer kinetics

MT Wyss - 2009 - zora.uzh.ch
The measurement of metabolism-related processes in vivo is a critical prerequisite for a
better understanding of brain metabolism and its relationship to the brain at work. For a long …

Instrumentation et méthodologies pour les études cérébrales in vivo sur modèles animaux: mesure cinétiques de radiotraceurs et imageries optiques en champ large.

F Pain - 2012 - hal.science
Les recherches que j'ai menées se sont successivement organisées selon deux
thématiques avec comme fil directeur l'interface entre l'instrumentation et les neurosciences …