ImmunoPET: concept, design, and applications

W Wei, ZT Rosenkrans, J Liu, G Huang, QY Luo… - Chemical …, 2020 - ACS Publications
Immuno-positron emission tomography (immunoPET) is a paradigm-shifting molecular
imaging modality combining the superior targeting specificity of monoclonal antibody (mAb) …

A molecular imaging primer: modalities, imaging agents, and applications

ML James, SS Gambhir - Physiological reviews, 2012 - journals.physiology.org
Molecular imaging is revolutionizing the way we study the inner workings of the human
body, diagnose diseases, approach drug design, and assess therapies. The field as a whole …

[HTML][HTML] Affibody molecules: engineered proteins for therapeutic, diagnostic and biotechnological applications

J Löfblom, J Feldwisch, V Tolmachev, J Carlsson… - FEBS letters, 2010 - Elsevier
Affibody molecules are a class of engineered affinity proteins with proven potential for
therapeutic, diagnostic and biotechnological applications. Affibody molecules are small (6.5 …

First-in-human molecular imaging of HER2 expression in breast cancer metastases using the 111In-ABY-025 affibody molecule

J Sörensen, D Sandberg, M Sandström… - Journal of nuclear …, 2014 - Soc Nuclear Med
The expression status of human epidermal growth factor receptor type 2 (HER2) predicts the
response of HER2-targeted therapy in breast cancer. ABY-025 is a small reengineered …

Micro-CT enables microlocalisation and quantification of Her2-targeted gold nanoparticles within tumour regions

JF Hainfeld, MJ O'Connor, FA Dilmanian… - The British journal of …, 2011 - birpublications.org
Objectives: Gold nanoparticles are of interest as potential in vivo diagnostic and therapeutic
agents, as X-ray contrast agents, drug delivery vehicles and radiation enhancers. The aim of …

Design and development of molecular imaging probes

K Chen, X Chen - Current topics in medicinal chemistry, 2010 - ingentaconnect.com
Molecular imaging, the visualization, characterization and measurement of biological
processes at the cellular, subcellular level, or even molecular level in living subjects, has …

[HTML][HTML] Affibody molecules as targeting vectors for PET imaging

V Tolmachev, A Orlova - Cancers, 2020 - mdpi.com
Affibody molecules are small (58 amino acids) engineered scaffold proteins that can be
selected to bind to a large variety of proteins with a high affinity. Their small size and high …

[HTML][HTML] Molecular optical imaging with radioactive probes

H Liu, G Ren, Z Miao, X Zhang, X Tang, P Han… - PloS one, 2010 - journals.plos.org
Background Optical imaging (OI) techniques such as bioluminescence and fluorescence
imaging have been widely used to track diseases in a non-invasive manner within living …

Design of an optimized scaffold for affibody molecules

J Feldwisch, V Tolmachev, C Lendel, N Herne… - Journal of molecular …, 2010 - Elsevier
Affibody molecules are non-immunoglobulin-derived affinity proteins based on a three-
helical bundle protein domain. Here, we describe the design process of an optimized …

Enzyme-mediated methodology for the site-specific radiolabeling of antibodies based on catalyst-free click chemistry

BM Zeglis, CB Davis, R Aggeler, HC Kang… - Bioconjugate …, 2013 - ACS Publications
An enzyme-and click chemistry-mediated methodology for the site-selective radiolabeling of
antibodies on the heavy chain glycans has been developed and validated. To this end, a …