Radiolabeled Cyclic RGD Peptides as Integrin αvβ3-Targeted Radiotracers: Maximizing Binding Affinity via Bivalency

S Liu - Bioconjugate chemistry, 2009 - ACS Publications
Integrin αvβ3 plays a significant role in tumor angiogenesis and is a receptor for the
extracellular matrix proteins with the exposed arginine-glycine-aspartic (RGD) tripeptide …

Peptides and peptide hormones for molecular imaging and disease diagnosis

S Lee, J Xie, X Chen - Chemical reviews, 2010 - ACS Publications
Molecular imaging techniques are now indispensable tools in modern diagnostics, because
they are highly specific and can provide biological information at the molecular level in living …

PET/CT imaging of integrin αvβ3 expression in human carotid atherosclerosis

AJ Beer, J Pelisek, P Heider, A Saraste… - JACC: Cardiovascular …, 2014 - jacc.org
Objectives: The goal of this study was to evaluate the feasibility of [18F] Galacto-RGD
positron emission tomography (PET)/computed tomography (CT) imaging of αvβ3 …

[HTML][HTML] Preliminary clinical application of RGD-containing peptides as PET radiotracers for imaging tumors

L Li, X Chen, J Yu, S Yuan - Frontiers in Oncology, 2022 - frontiersin.org
Angiogenesis is a common feature of many physiological processes and pathological
conditions. RGD-containing peptides can strongly bind to integrin αvβ3 expressed on …

Optical and multimodality molecular imaging: insights into atherosclerosis

FA Jaffer, P Libby, R Weissleder - Arteriosclerosis, thrombosis, and …, 2009 - Am Heart Assoc
Imaging approaches that visualize molecular targets rather than anatomic structures aim to
illuminate vital molecular and cellular aspects of atherosclerosis biology in vivo. Several …

Radiolabeled cyclic RGD peptide bioconjugates as radiotracers targeting multiple integrins

S Liu - Bioconjugate chemistry, 2015 - ACS Publications
Angiogenesis is a requirement for tumor growth and metastasis. The angiogenic process
depends on vascular endothelial cell migration and invasion, and is regulated by various …

Multicomponent Reactions for de Novo Synthesis of BODIPY Probes: In Vivo Imaging of Phagocytic Macrophages

A Vazquez-Romero, N Kielland… - Journal of the …, 2013 - ACS Publications
Multicomponent reactions are excellent tools to generate complex structures with broad
chemical diversity and fluorescent properties. Herein we describe the adaptation of the …

[HTML][HTML] Radiolabeled cyclic RGD peptides as radiotracers for imaging tumors and thrombosis by SPECT

Y Zhou, S Chakraborty, S Liu - Theranostics, 2011 - ncbi.nlm.nih.gov
The integrin family is a group of transmembrane glycoprotein comprised of 19 α-and 8 β-
subunits that are expressed in 25 different α/β heterodimeric combinations on the cell …

Evaluation of αvβ3 Integrin-Targeted Positron Emission Tomography Tracer 18F-Galacto-RGD for Imaging of Vascular Inflammation in Atherosclerotic Mice

I Laitinen, A Saraste, E Weidl, T Poethko… - Circulation …, 2009 - Am Heart Assoc
Background—18F-Galacto-RGD is a positron emission tomography (PET) tracer binding to
αvβ3 integrin that is expressed by macrophages and endothelial cells in atherosclerotic …

Comparison of in vivo targeting ability between cRGD and collagen-targeting peptide conjugated nano-carriers for atherosclerosis

M Kim, A Sahu, GB Kim, GH Nam, W Um… - Journal of Controlled …, 2018 - Elsevier
Atherosclerosis plaque is a major cause of cardiovascular diseases across the globe and a
silent killer. There are no physical symptoms of the disease in its early stage and current …