Radiolabeled Cyclic RGD Peptides as Integrin αvβ3-Targeted Radiotracers: Maximizing Binding Affinity via Bivalency
S Liu - Bioconjugate chemistry, 2009 - ACS Publications
Integrin αvβ3 plays a significant role in tumor angiogenesis and is a receptor for the
extracellular matrix proteins with the exposed arginine-glycine-aspartic (RGD) tripeptide …
extracellular matrix proteins with the exposed arginine-glycine-aspartic (RGD) tripeptide …
Peptides and peptide hormones for molecular imaging and disease diagnosis
Molecular imaging techniques are now indispensable tools in modern diagnostics, because
they are highly specific and can provide biological information at the molecular level in living …
they are highly specific and can provide biological information at the molecular level in living …
PET/CT imaging of integrin αvβ3 expression in human carotid atherosclerosis
Objectives: The goal of this study was to evaluate the feasibility of [18F] Galacto-RGD
positron emission tomography (PET)/computed tomography (CT) imaging of αvβ3 …
positron emission tomography (PET)/computed tomography (CT) imaging of αvβ3 …
[HTML][HTML] Preliminary clinical application of RGD-containing peptides as PET radiotracers for imaging tumors
L Li, X Chen, J Yu, S Yuan - Frontiers in Oncology, 2022 - frontiersin.org
Angiogenesis is a common feature of many physiological processes and pathological
conditions. RGD-containing peptides can strongly bind to integrin αvβ3 expressed on …
conditions. RGD-containing peptides can strongly bind to integrin αvβ3 expressed on …
Optical and multimodality molecular imaging: insights into atherosclerosis
Imaging approaches that visualize molecular targets rather than anatomic structures aim to
illuminate vital molecular and cellular aspects of atherosclerosis biology in vivo. Several …
illuminate vital molecular and cellular aspects of atherosclerosis biology in vivo. Several …
Radiolabeled cyclic RGD peptide bioconjugates as radiotracers targeting multiple integrins
S Liu - Bioconjugate chemistry, 2015 - ACS Publications
Angiogenesis is a requirement for tumor growth and metastasis. The angiogenic process
depends on vascular endothelial cell migration and invasion, and is regulated by various …
depends on vascular endothelial cell migration and invasion, and is regulated by various …
Multicomponent Reactions for de Novo Synthesis of BODIPY Probes: In Vivo Imaging of Phagocytic Macrophages
A Vazquez-Romero, N Kielland… - Journal of the …, 2013 - ACS Publications
Multicomponent reactions are excellent tools to generate complex structures with broad
chemical diversity and fluorescent properties. Herein we describe the adaptation of the …
chemical diversity and fluorescent properties. Herein we describe the adaptation of the …
[HTML][HTML] Radiolabeled cyclic RGD peptides as radiotracers for imaging tumors and thrombosis by SPECT
Y Zhou, S Chakraborty, S Liu - Theranostics, 2011 - ncbi.nlm.nih.gov
The integrin family is a group of transmembrane glycoprotein comprised of 19 α-and 8 β-
subunits that are expressed in 25 different α/β heterodimeric combinations on the cell …
subunits that are expressed in 25 different α/β heterodimeric combinations on the cell …
Evaluation of αvβ3 Integrin-Targeted Positron Emission Tomography Tracer 18F-Galacto-RGD for Imaging of Vascular Inflammation in Atherosclerotic Mice
I Laitinen, A Saraste, E Weidl, T Poethko… - Circulation …, 2009 - Am Heart Assoc
Background—18F-Galacto-RGD is a positron emission tomography (PET) tracer binding to
αvβ3 integrin that is expressed by macrophages and endothelial cells in atherosclerotic …
αvβ3 integrin that is expressed by macrophages and endothelial cells in atherosclerotic …
Comparison of in vivo targeting ability between cRGD and collagen-targeting peptide conjugated nano-carriers for atherosclerosis
Atherosclerosis plaque is a major cause of cardiovascular diseases across the globe and a
silent killer. There are no physical symptoms of the disease in its early stage and current …
silent killer. There are no physical symptoms of the disease in its early stage and current …