Cell therapies represent a rapidly emerging class of new therapeutics. They are intended
and developed for the treatment of some of the most prevalent human diseases, including …

The first reporter systems were developed in the early 1980s and were based on measuring
the activity of an enzyme—as a surrogate measure of promoter-driven transcriptional activity …

Cerenkov radiation is a phenomenon where optical photons are emitted when a charged
particle moves faster than the speed of light for the medium in which it travels. Recently, we …

Positron emission tomography (PET) imaging reporter genes (IRGs) and PET reporter
probes (PRPs) are amongst the most valuable tools for gene and cell therapy. PET …

Background: Hypoxia, which is commonly observed in areas of primary tumours and of
metastases, influences response to treatment. However, its characterisation has so far …

There remains an urgent need for the noninvasive tracking of transfused chimeric antigen
receptor (CAR) T cells to determine their biodistribution, viability, expansion, and antitumor …

Immunotherapy is a relatively new treatment regimen for cancer, and it is based on the
modulation of the immune system to battle cancer. Immunotherapies can be classified as …

Chimeric antigen receptor (CAR) T-cell therapies have evolved as breakthrough treatment
options for the management of hematological malignancies and are also being developed …

Purpose: To engineer a dual human and murine Thy1-binding single-chain-antibody ligand
(Thy1-scFv) for contrast microbubble–enhanced ultrasound molecular imaging of pancreatic …

The overall objective of this study is to non-invasively image and assess tumor targeting and
retention of directly labeled T-lymphocytes following their adoptive transfer in mice. T …