Smoking and pain: pathophysiology and clinical implications

Y Shi, TN Weingarten, CB Mantilla… - The Journal of the …, 2010 - pubs.asahq.org
Cigarette smoke, which serves as a nicotine delivery vehicle in humans, produces profound
changes in physiology. Experimental studies suggest that nicotine has analgesic properties …

Addiction‐related neuroadaptations following chronic nicotine exposure

L Wills, PJ Kenny - Journal of neurochemistry, 2021 - Wiley Online Library
The addiction‐relevant molecular, cellular, and behavioral actions of nicotine are derived
from its stimulatory effects on neuronal nicotinic acetylcholine receptors (nAChRs) in the …

Smoking, nicotine and neuropsychiatric disorders

P Dome, J Lazary, MP Kalapos, Z Rihmer - Neuroscience & Biobehavioral …, 2010 - Elsevier
Tobacco smoking is an extremely addictive and harmful form of nicotine (NIC) consumption,
but unfortunately also the most prevalent. Although disproportionately high frequencies of …

[HTML][HTML] When your brain looks older than expected: combined lifestyle risk and BrainAGE

N Bittner, C Jockwitz, K Franke, C Gaser… - Brain Structure and …, 2021 - Springer
Lifestyle may be one source of unexplained variance in the great interindividual variability of
the brain in age-related structural differences. While physical and social activity may protect …

[HTML][HTML] Pathophysiology of nAChRs: limbic circuits and related disorders

YS Mineur, AR Soares, IM Etherington… - Pharmacological …, 2023 - Elsevier
Human epidemiological studies have identified links between nicotine intake and stress
disorders, including anxiety, depression and PTSD. Here we review the clinical evidence for …

Imaging addiction: D2 receptors and dopamine signaling in the striatum as biomarkers for impulsivity

P Trifilieff, D Martinez - Neuropharmacology, 2014 - Elsevier
Dependence to drugs of abuse is closely associated with impulsivity, or the propensity to
choose a lower, but immediate, reward over a delayed, but more valuable outcome. Here …

[HTML][HTML] Dual role of nicotine in addiction and cognition: a review of neuroimaging studies in humans

AJ Jasinska, T Zorick, AL Brody, EA Stein - Neuropharmacology, 2014 - Elsevier
Substantial evidence demonstrates both nicotine's addiction liability and its cognition-
enhancing effects. However, the neurobiological mechanisms underlying nicotine's impact …

[HTML][HTML] Nicotine promotes tumor growth and metastasis in mouse models of lung cancer

R Davis, W Rizwani, S Banerjee, M Kovacs, E Haura… - PloS one, 2009 - journals.plos.org
Background Nicotine is the major addictive component of tobacco smoke. Although nicotine
is generally thought to have limited ability to initiate cancer, it can induce cell proliferation …

Nicotinic, glutamatergic and dopaminergic synaptic transmission and plasticity in the mesocorticolimbic system: focus on nicotine effects

F Pistillo, F Clementi, M Zoli, C Gotti - Progress in neurobiology, 2015 - Elsevier
Cigarette smoking is currently the leading cause of preventable deaths and disability
throughout the world, being responsible for about five million premature deaths/year …

Brain imaging changes associated with risk factors for cardiovascular and cerebrovascular disease in asymptomatic patients

JI Friedman, CY Tang, HJ de Haas… - JACC: cardiovascular …, 2014 - jacc.org
Reviews of imaging studies assessing the brain effects of vascular risk factors typically
include a substantial number of studies with subjects with a history of symptomatic …