Cerebrovascular P-glycoprotein (P-gp) acts at the blood–brain barrier (BBB) as an active
cell membrane efflux pump for several endogenous and exogenous compounds. Age …

Background Multiple sclerosis (MS) is a demyelinating and inflammatory disease of the
central nervous system. Its diagnosis is clinical, often confirmed by magnetic resonance …

Abstract Objective:[F‐18] Nifene is a PET radioligand developed to image α4β2* nicotinic
acetylcholine receptors (nAChR) in the brain. This work assesses the in vivo binding and …

There are only 2 currently available radioligands, 2-18F-FA and 6-18F-FA, for quantitative
PET of the main cerebral subtype of nicotinic acetylcholine receptors (α4β2-nAChRs) in …

MicroPET imaging studies using 18 F-nifene, a new positron emission tomography (PET)
radiotracer for nicotinic acetylcholinergic receptors (nAChR) α4β2 receptors in rats, have …

BACKGROUND: Marked interindividual differences in vulnerability to nicotine dependence
exist, but factors underlying such differences are not well understood. The midbrain α4β2 …

Rationale Although nicotine exposure upregulates the α4β2* subtype of nicotinic
acetylcholine receptors (nAChRs), the upregulation of nAChRs in non-human primates …

Recent developments in radiochemistry have opened new vistas for investigations of
nicotinergic acetylcholine receptors (nAChRs) in living brain by positron emission …

Innovations in radiochemistry and pharmacology are opening new vistas for studies of
nicotinic acetylcholine receptors (nAChRs) in human brain by positron emission tomography …

The P-glycoprotein (P-gp), an efflux transporter expressed at the blood-brain barrier (BBB),
limits the cerebral passage of many drugs. This thesis aimed to study, validate, and optimize …