Neutrophils and monocytes belong to the first line of immune defence cells and are recruited
to sites of inflammation during infection or sterile injury. Both cells contain huge amounts of …

OBJECTIVE. A significant challenge facing traditional cancer therapies is their propensity to
significantly harm normal tissue. The recent clinical success of targeting therapies by …

Traumatic optic neuropathy (TON) is an acute injury of the optic nerve secondary to trauma.
Loss of retinal ganglion cells (RGCs) is a key pathological process in TON, yet mechanisms …

Background Osteoarticular infections are uncommon and required a multimodal approach
for diagnosis. Imaging forms an important component of this multimodal approach …

OBJECTIVE: In this study we sought to assess the efficacy of a technetium-99m (Tc-99m)-
labeled third-generation cephalosporin as an infection imaging agent in the accurate …

INTRODUCTION: Vascular adhesion protein-1 (VAP-1) is an infection/inflammation-
inducible endothelial glycoprotein. Based on our previous studies, the most VAP-1-selective …

Invasive fungal infections are recognized as an important cause of morbidity and mortality in
the immunocompromised host. Rapid initiation of adequate antifungal treatment is often …

A new heterobivalent peptide ligand specifically targeting polymorphonuclear leukocytes
(PMNs) with favorable pharmacological parameters to monitor sites of inflammation for …

Diabetic Foot Infections (DFIs) are associated with increased morbidity, an economic burden
on patients, their families and healthcare systems and increased mortality. Early diagnosis …

Background Our previous studies showed that neutrophil infiltration and activation plays an
important role in the pathogenesis of abdominal aortic aneurysms (AAA). However, there is …