Log normal distribution of cellular uptake of radioactivity: implications for biologic responses to radiopharmaceuticals

PVSV Neti, RW Howell - Journal of Nuclear Medicine, 2006 - Soc Nuclear Med
It is widely recognized that radiopharmaceuticals are generally distributed nonuniformly in
tissues. Such nonuniformities are observed over the entire range of spatial levels, ranging …

[HTML][HTML] Large-scale in vitro microdosimetry via live cell microscopy imaging: implications for radiosensitivity and RBE evaluations in alpha-emitter …

R Bastiaannet, I Liatsou, RF Hobbs… - Journal of translational …, 2023 - Springer
Background Alpha-emitter radiopharmaceutical therapy (αRPT) has shown promising
outcomes in metastatic disease. However, the short range of the alpha particles necessitates …

Lognormal distribution of cellular uptake of radioactivity: statistical analysis of α-particle track autoradiography

PVSV Neti, RW Howell - Journal of Nuclear Medicine, 2008 - Soc Nuclear Med
Recently, the distribution of radioactivity among a population of cells labeled with 210Po
was shown to be well described by a lognormal (LN) distribution function (J Nucl Med. 2006; …

Further explorations of cellular uptake of radioactivity

WE Bolch - Journal of Nuclear Medicine, 2008 - Soc Nuclear Med
It is widely recognized in the field of internal emitter therapy that radiopharmaceuticals are
distributed nonuniformly within tissues of localization, and this nonuniformity extends to all …

[BOOK][B] Alpha-radioimmunotherapy with At-211: Evaluations and imaging on normal tissues and tumors

T Bäck - 2011 - gupea.ub.gu.se
Alpha-radioimmunotherapy (alpha-RIT) is an internal conformal radiotherapy at the cellular
level using alpha-particle emitting radionuclides. Alpha-particles have a very short range in …

[HTML][HTML] Log Normal Distribution of Cellular Uptake of Radioactivity: Statistical Analysis of Alpha Particle Track Autoradiography

PVSV Neti, RW Howell - Journal of nuclear medicine: official …, 2006 - ncbi.nlm.nih.gov
Recently, the distribution of radioactivity among a population of cells labeled with 210 Po
was shown to be well described by a log normal distribution function (J Nucl Med 47, 6 …