Recent advances in noninvasive imaging modalities have opened endless opportunities for
molecular diagnostic and therapeutic procedures. The term “molecular imaging” is broadly …

The search for novel image contrasts has been a major driving force in the magnetic
resonance (MR) research community, in order to gain further information on the body's …

Glutamate, a major neurotransmitter in the brain, shows a pH-and concentration-dependent
chemical exchange saturation transfer effect (GluCEST) between its amine group and bulk …

Objective: Clinical and preclinical evidence suggests a hyperactive glutamatergic system in
clinical depression. Recently, the metabotropic glutamate receptor 5 (mGluR5) has been …

Chemical exchange saturation transfer (CEST) is a magnetic resonance imaging (MRI)
contrast enhancement technique that enables indirect detection of metabolites with …

Allosteric receptor modulation is an attractive concept in drug targeting because it offers
important potential advantages over conventional orthosteric agonism or antagonism …

To accelerate the discovery of novel small molecule central nervous system (CNS) positron
emission tomography (PET) ligands, we aimed to define a property space that would …

Glutamate (Glu) is a major excitatory neurotransmitter in the brain and has been shown to
decrease in the early stages of Alzheimer's disease (AD). Using a glutamate chemical …

The positron emission tomography (PET) molecular imaging technique has gained its
universal value as a remarkable tool for medical diagnosis and biomedical research …

Several studies provide information useful to our understanding of restless legs syndrome
(RLS), using various imaging techniques to investigate different aspects putatively involved …