During the past several decades, numerous studies have provided insights into biological
characteristics of cancer cells and identified various hallmarks of cancer acquired in the …

This work designs a telomerase-responsive mesoporous silica nanoparticle (MSN) to realize
in situ “off-on” imaging of intracellular telomerase activity. In the wrapping DNA (O1) sealed …

Positron emission tomography (PET) is a noninvasive molecular imaging technology that is
becoming increasingly important for the measurement of physiologic, biochemical, and …

Telomere maintenance is a universal hallmark of cancer. Most tumors including low-grade
oligodendrogliomas use telomerase reverse transcriptase (TERT) expression for telomere …

Background Telomerase reverse transcriptase (TERT) is essential for tumor proliferation,
including in low-grade oligodendrogliomas (LGOGs). Since TERT is silenced in normal …

TERT promoter mutations are a hallmark of glioblastoma (GBM). Accordingly, TERT and
GABPB1, a subunit of the upstream mutant TERT promoter transcription factor GABP, are …

" Molecular Imaging: Fundamentals and Applications" is a comprehensive monograph which
describes not only the theory of the underlying algorithms and key technologies but also …

The mouse double-minute 2 (MDM2) oncogene, amplified or overexpressed in many human
cancers, has been suggested to be a novel target for cancer therapy. Visualization of MDM2 …

The remarkable efforts that are made on molecular imaging technologies demonstrate its
potential importance and range of applications. The generation of disease-specific animal …

Small-interference RNAs (siRNAs) are short, double-strand RNA molecules that target
specific messenger RNAs for degradation via the process termed RNA interference. The …